Gene

spint1a

ID
ZDB-GENE-040426-2169
Name
serine peptidase inhibitor, Kunitz type 1 a
Symbol
spint1a Nomenclature History
Previous Names
  • hai1a (1)
  • spint1l
  • cb376 (1)
  • sb:cb376
  • serine protease inhibitor HGFAI (1)
  • zgc:64075
Type
protein_coding_gene
Location
Chr: 17 Mapping Details/Browsers
Description
Enables peptidase inhibitor activity. Involved in regulation of inflammatory response. Acts upstream of or within several processes, including collagen fibril organization; epidermis development; and neutrophil chemotaxis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including apical ectodermal ridge; digestive system; fin fold pectoral fin bud; periderm; and sensory system. Used to study psoriasis. Orthologous to human SPINT1 (serine peptidase inhibitor, Kunitz type 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
11 figures from 5 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
42 figures from 13 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With spint1a Human Ortholog
No data available
Associated With spint1a Via Experimental Models
Human Disease Fish Conditions Citations
psoriasis spint1ahi2217Tg/hi2217Tg; nz50Tg standard conditions Martínez-Navarro et al., 2020
psoriasis spint1ahi2217Tg/hi2217Tg standard conditions Martínez-Navarro et al., 2020
psoriasis spint1ahi2217Tg/hi2217Tg; nc1Tg standard conditions Martínez-Navarro et al., 2020
1 - 3 of 3
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR020901 Proteinase inhibitor I2, Kunitz, conserved site
Conserved_site IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
Domain IPR002223 Pancreatic trypsin inhibitor Kunitz domain
Domain IPR011106 Seven cysteines, N-terminal
Domain IPR013980 MANSC domain
1 - 5 of 11 Show all
Domain Details Per Protein
Protein Additional Resources Length Immunoglobulin-like fold LDL receptor-like superfamily Low-density lipoprotein (LDL) receptor class A, conserved site Low-density lipoprotein (LDL) receptor class A repeat MANSC domain Pancreatic trypsin inhibitor Kunitz domain Pancreatic trypsin inhibitor Kunitz domain superfamily PKD/Chitinase domain PKD domain superfamily Proteinase inhibitor I2, Kunitz, conserved site Seven cysteines, N-terminal
UniProtKB:A0A2R8QCE4 InterPro 523
UniProtKB:Q7T363 InterPro 516
UniProtKB:A0A8M9P036 InterPro 506
1 - 3 of 3
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA spint1a-201 (1)
Ensembl
Ensembl 2,343 nt
ZFIN BLAST
mRNA spint1a-202 (1)
Ensembl
Ensembl 3,726 nt
ZFIN BLAST
mRNA spint1a-203 (1)
Ensembl
Ensembl 3,651 nt
ZFIN BLAST
mRNA spint1a-204 (1)
Ensembl
Ensembl 3,702 nt
ZFIN BLAST
1 - 4 of 4
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations
Your Input Welcome
We welcome your input and comments. Please use this form to recommend updates to the information in ZFIN. We appreciate as much detail as possible and references as appropriate. We will review your comments promptly.