Gene
enpp2
- ID
- ZDB-GENE-040426-1156
- Name
- ectonucleotide pyrophosphatase/phosphodiesterase 2
- Symbol
- enpp2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Enables alkylglycerophosphoethanolamine phosphodiesterase activity and lysophospholipase activity. Acts upstream of or within several processes, including Kupffer's vesicle development; circulatory system development; and hemangioblast cell differentiation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including axial blood vessel; central nervous system; digestive system; head; and pleuroperitoneal region. Orthologous to human ENPP2 (ectonucleotide pyrophosphatase/phosphodiesterase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 17 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa6410 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa36049 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa42664 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| zf3358 | Allele with one deletion | Exon 7 | Splicing Variant, Premature Stop | TALEN |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-enpp2 | Wheeler et al., 2015 | |
| CRISPR2-enpp2 | Wheeler et al., 2015 | |
| MO1-enpp2 | N/A | (3) |
| MO2-enpp2 | N/A | (2) |
| MO3-enpp2 | N/A | Yuelling et al., 2012 |
| MO4-enpp2 | N/A | Yuelling et al., 2012 |
| MO5-enpp2 | N/A | Lai et al., 2012 |
| MO6-enpp2 | N/A | Li et al., 2014 |
| TALEN1-enpp2 | Kise et al., 2019 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001212 | Somatomedin B domain |
| Domain | IPR001604 | DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase domain |
| Domain | IPR020436 | Somatomedin B domain, chordata |
| Domain | IPR020821 | ENPP1-3/EXOG-like, endonuclease/phosphodiesterase domain |
| Family | IPR002591 | Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase |
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Domain Details Per Protein
| Protein | Length | Alkaline-phosphatase-like, core domain superfamily | DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase domain | DNA/RNA non-specific endonuclease superfamily | ENPP1-3/EXOG-like, endonuclease/phosphodiesterase domain | His-Me finger superfamily | Somatomedin B domain | Somatomedin B domain, chordata | Somatomedin B-like domain superfamily | Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6PGY9
|
850 | |||||||||
|
UniProtKB:A0A8M3AIW9
|
854 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-93I7 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-59G8 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:63550 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_200603 (1) | 3044 nt | ||
| Genomic | GenBank:CU104700 (2) | 155195 nt | ||
| Polypeptide | UniProtKB:A0A8M3AIW9 (1) | 854 aa |
- Kawaguchi, M., Okabe, T., Okudaira, S., Hama, K., Kano, K., Nishimasu, H., Nakagawa, H., Ishitani, R., Kojima, H., Nureki, O., Aoki, J., Nagano, T. (2020) Identification of potent in vivo autotaxin inhibitors that bind to both hydrophobic pocket and channel in the catalytic domain. Journal of medicinal chemistry. 63(6):3188-3204
- Kaya, B., Doñas, C., Wuggenig, P., Diaz, O.E., Morales, R.A., Melhem, H., Swiss IBD. Cohort Investigators, Hernández, P.P., Kaymak, T., Das, S., Hruz, P., Franc, Y., Geier, F., Ayata, C.K., Villablanca, E.J., Niess, J.H. (2020) Lysophosphatidic Acid-Mediated GPR35 Signaling in CX3CR1+ Macrophages Regulates Intestinal Homeostasis. Cell Reports. 32:107979
- Kise, R., Okasato, R., Kano, K., Inoue, A., Kawahara, A., Aoki, J. (2019) Identification and biochemical characterization of a second zebrafish autotaxin gene. Journal of biochemistry. 165(3):269-275
- Wakisaka, N., Miyasaka, N., Koide, T., Masuda, M., Hiraki-Kajiyama, T., Yoshihara, Y. (2017) An Adenosine Receptor for Olfaction in Fish. Current biology : CB. 27(10):1437-1447.e4
- Frisca, F., Colquhoun, D., Goldshmit, Y., Änkö, M.L., Pébay, A., Kaslin, J. (2016) Role of ectonucleotide pyrophosphatase/phosphodiesterase 2 in the midline axis formation of zebrafish. Scientific Reports. 6:37678
- Nishioka, T., Arima, N., Kano, K., Hama, K., Itai, E., Yukiura, H., Kise, R., Inoue, A., Kim, S.H., Solnica-Krezel, L., Moolenaar, W.H., Chun, J., Aoki, J. (2016) ATX-LPA1 axis contributes to proliferation of chondrocytes by regulating fibronectin assembly leading to proper cartilage formation. Scientific Reports. 6:23433
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Wheeler, N.A., Lister, J.A., Fuss, B. (2015) The Autotaxin-Lysophosphatidic Acid Axis Modulates Histone Acetylation and Gene Expression during Oligodendrocyte Differentiation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 35:11399-414
- Li, H., Yue, R., Wei, B., Gao, G., Du, J., Pei, G. (2014) Lysophosphatidic acid acts as a nutrient-derived developmental cue to regulate early hematopoiesis. The EMBO journal. 33(12):1383-96
- Nakanaga, K., Hama, K., Kano, K., Sato, T., Yukiura, H., Inoue, A., Saigusa, D., Tokuyama, H., Tomioka, Y., Nishina, H., Kawahara, A., and Aoki, J. (2014) Overexpression of autotaxin, a lysophosphatidic acid-producing enzyme, enhances cardia bifida induced by hypo-sphingosine-1-phosphate signaling in zebrafish embryo. Journal of biochemistry. 155(4):235-41
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