ZFIN ID: ZDB-GENE-040426-1156
Gene Name: ectonucleotide pyrophosphatase/phosphodiesterase 2
Gene Symbol: enpp2    Nomenclature History

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Previous Names: atx (1), autotaxin (1), zgc:63550

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 16 Mapping Details/Browsers
Description: Exhibits lysophospholipase activity and phosphoric diester hydrolase activity. Involved in several processes, including Kupffer's vesicle development; animal organ development; and oligodendrocyte differentiation. Predicted to localize to extracellular space. Is expressed in several structures, including axial blood vessel; axis; central nervous system; head; and shield. Orthologous to human ENPP2 (ectonucleotide pyrophosphatase/phosphodiesterase 2).
Genome Resources: Alliance (1),  Gene:100332039 (1),  Ensembl(GRCz11):ENSDARG00000011257 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa6410 Point Mutation Unknown Splice Site ENU
sa36049 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa42664 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-enpp2
    1
    CRISPR2-enpp2
    1
    MO1-enpp2 N/A 3
    MO2-enpp2 N/A 2
    MO3-enpp2 N/A 1
    MO4-enpp2 N/A 1
    MO5-enpp2 N/A 1
    MO6-enpp2 N/A 1
    DISEASE ASSOCIATED WITH enpp2 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH enpp2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cartilage development (more)
    Cellular Component extracellular space (more)
    Molecular Function lysophospholipase activity (more)
    GO Terms (all 29)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA enpp2-201 (1)    Ensembl 3119
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab4-enpp2 polyclonal Rabbit IHC, WB Abnova
    3
    Ab3-enpp2 polyclonal IgG Rabbit WB Cayman Chemical Company
    2
    Ab2-enpp2 polyclonal WB 1
    Ab1-enpp2 polyclonal Rat WB 1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM enpp2 No data available
    MARKER RELATIONSHIPS
    enpp2 Contained in: [BAC] CH211-93I7 (1), DKEY-59G8 (1) (order this)
    enpp2 Encodes: [cDNA] MGC:63550 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_200603 (1) 3044 nt
    Genomic GenBank:CU104700 (1) 155195 nt
    Select Tool
    Polypeptide UniProtKB:Q6PGY9 (1) 850 aa
    Sequence Information (all 13)
    ORTHOLOGY for enpp2 ( Chr: 16 )
    CITATIONS (26)