Gene
enpp2
- ID
- ZDB-GENE-040426-1156
- Name
- ectonucleotide pyrophosphatase/phosphodiesterase 2
- Symbol
- enpp2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Enables alkylglycerophosphoethanolamine phosphodiesterase activity and phosphatidylcholine lysophospholipase activity. Acts upstream of or within several processes, including Kupffer's vesicle development; circulatory system development; and hemangioblast cell differentiation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including axial blood vessel; central nervous system; digestive system; head; and pleuroperitoneal region. Orthologous to human ENPP2 (ectonucleotide pyrophosphatase/phosphodiesterase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 17 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001212 | Somatomedin B domain |
| Domain | IPR001604 | DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase domain |
| Domain | IPR020436 | Somatomedin B domain, chordata |
| Domain | IPR020821 | ENPP1-3/EXOG-like, endonuclease/phosphodiesterase domain |
| Family | IPR002591 | Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase |
| Homologous_superfamily | IPR017850 | Alkaline-phosphatase-like, core domain superfamily |
| Homologous_superfamily | IPR036024 | Somatomedin B-like domain superfamily |
| Homologous_superfamily | IPR044925 | His-Me finger superfamily |
| Homologous_superfamily | IPR044929 | DNA/RNA non-specific endonuclease superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Alkaline-phosphatase-like, core domain superfamily | DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase domain | DNA/RNA non-specific endonuclease superfamily | ENPP1-3/EXOG-like, endonuclease/phosphodiesterase domain | His-Me finger superfamily | Somatomedin B domain | Somatomedin B domain, chordata | Somatomedin B-like domain superfamily | Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6PGY9 | InterPro | 850 | |||||||||
| UniProtKB:A0A8M3AIW9 | InterPro | 854 |
Interactions and Pathways
No data available
Plasmids
No data available