ZFIN Gene: enpp2

ZFIN ID: ZDB-GENE-040426-1156

ZFIN ID: ZDB-GENE-040426-1156

Gene Name:

ectonucleotide pyrophosphatase/phosphodiesterase 2

Gene Symbol:

enpp2 Nomenclature History

Previous Names:

atx (1), autotaxin (1), zgc:63550

Gene Type:

protein_coding_gene

Location:

Chr: 16 Mapping Details/Browsers

Description:

Exhibits lysophospholipase activity and phosphoric diester hydrolase activity. Involved in several processes, including Kupffer's vesicle development; animal organ development; and oligodendrocyte differentiation. Predicted to localize to extracellular space. Is expressed in several structures, including axial blood vessel; axis; central nervous system; head; and shield. Orthologous to human ENPP2 (ectonucleotide pyrophosphatase/phosphodiesterase 2).

Genome Resources:

Alliance (1), Gene:100332039 (1), Ensembl(GRCz11):ENSDARG00000011257 (2)

GENE EXPRESSION
All Expression Data:	8 figures from 5 publications
Wild-type Stages, Structures:	Cleavage:2-cell (0.75h-1.0h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
	axis brain chondrocyte cranial vasculature dorsal aorta floor plate head pectoral fin pharyngeal arch posterior cardinal vein shield spinal cord trabecula cranii whole organism anterior-posterior axis whole organism yolk syncytial layer

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
sa6410	Point Mutation	Unknown	Splice Site	ENU
sa36049	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa42664	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)

Sequence Targeting Reagents

Targeting Reagent	Created Alleles	Publications
CRISPR1-enpp2		1
CRISPR2-enpp2		1
MO1-enpp2	N/A	3
MO2-enpp2	N/A	2
MO3-enpp2	N/A	1
MO4-enpp2	N/A	1
MO5-enpp2	N/A	1
MO6-enpp2	N/A	1

PHENOTYPE

Data:

17 figures from 5 publications

Observed in:

DISEASE ASSOCIATED WITH enpp2 HUMAN ORTHOLOG No data available

DISEASE ASSOCIATED WITH enpp2 VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	cartilage development (more)
Cellular Component	extracellular space (more)
Molecular Function	lysophospholipase activity (more)

GO Terms (all 29)

PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available

TRANSCRIPTS
Type	Name	Length (nt)	Analysis
mRNA	enpp2-201 (1)	3119	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Browsers: UCSC, NCBI, Ensembl, ZFIN

INTERACTIONS AND PATHWAYS

ANTIBODIES

Name	Type	Isotype	Host Organism	Assay	Source	Publications
Ab4-enpp2	polyclonal		Rabbit	IHC, WB	Abnova	3
Ab3-enpp2	polyclonal	IgG	Rabbit	WB	Cayman Chemical Company	2
Ab2-enpp2	polyclonal			WB		1
Ab1-enpp2	polyclonal		Rat	WB		1

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM enpp2 No data available

MARKER RELATIONSHIPS

enpp2 Contained in:	[BAC] CH211-93I7 (1), DKEY-59G8 (1) (order this)
enpp2 Encodes:	[cDNA] MGC:63550 (1)

SEQUENCE INFORMATION

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_200603 (1)	3044 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:CU104700 (1)	155195 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:Q6PGY9 (1)	850 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Sequence Information (all 13)

ORTHOLOGY for enpp2 ( Chr: 16 )

CITATIONS (26)

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