ZFIN ID: ZDB-GENE-040426-1156
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Gene Name: ectonucleotide pyrophosphatase/phosphodiesterase 2
Gene Symbol: enpp2    Nomenclature History

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Previous Names: atx (1), autotaxin (1), zgc:63550

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 16 Mapping Details/Browsers
Description: Exhibits lysophospholipase activity and phosphoric diester hydrolase activity. Involved in several processes, including Kupffer's vesicle development; animal organ development; and oligodendrocyte differentiation. Predicted to localize to the extracellular space. Is expressed in several structures, including axial blood vessel; axis; central nervous system; head; and shield. Orthologous to human ENPP2 (ectonucleotide pyrophosphatase/phosphodiesterase 2).
Genome Resources: Alliance (1),  Gene:100332039 (1),  Ensembl(GRCz11):ENSDARG00000011257 (2)
GENE EXPRESSION
All Expression Data: 8 figures from 5 publications
Wild-type Stages, Structures: Cleavage:2-cell (0.75h-1.0h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa6410 Point Mutation Unknown Splice Site ENU
sa36049 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa42664 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-enpp2
    		1
    CRISPR2-enpp2
    		1
    MO1-enpp2 N/A 3
    MO2-enpp2 N/A 2
    MO3-enpp2 N/A 1
    MO4-enpp2 N/A 1
    MO5-enpp2 N/A 1
    MO6-enpp2 N/A 1
    PHENOTYPE
    Data: 17 figures from 5 publications
    Observed in:
    DISEASE ASSOCIATED WITH enpp2 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH enpp2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cartilage development (more)
    Cellular Component extracellular space (more)
    Molecular Function lysophospholipase activity (more)
    GO Terms (all 29)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR001212 Somatomedin B domain
    Domain IPR001604 DNA/RNA non-specific endonuclease
    Family IPR002591 Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase
    Homologous_superfamily IPR017850 Alkaline-phosphatase-like, core domain superfamily
    Domain IPR020436 Somatomedin B, chordata
    Domain IPR020821 Extracellular Endonuclease, subunit A
    Family IPR029881 Ectonucleotide pyrophosphatase/phosphodiesterase family member 2
    Homologous_superfamily IPR036024 Somatomedin B-like domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA enpp2-201 (1)    Ensembl 3119
    Select Tool
    Browsers: UCSC,  NCBI,  Ensembl,  ZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab4-enpp2 polyclonal Rabbit IHC, WB Abnova
    		3
    Ab3-enpp2 polyclonal IgG Rabbit WB Cayman Chemical Company
    		2
    Ab2-enpp2 polyclonal WB 1
    Ab1-enpp2 polyclonal Rat WB 1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM enpp2 No data available
    MARKER RELATIONSHIPS
    enpp2 Contained in: [BAC] CH211-93I7 (1), DKEY-59G8 (1) (order this)
    enpp2 Encodes: [cDNA] MGC:63550 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_200603 (1) 3044 bp
    Select Tool
    Genomic GenBank:CU104700 (1) 155195 bp
    Select Tool
    Polypeptide UniProtKB:Q6PGY9 (1) 850 aa
    Select Tool
    Sequence Clusters UniGene:81765 (1)
    Sequence Information (all 14)
    ORTHOLOGY for enpp2 ( Chr: 16 )
    CITATIONS (26)