ZFIN ID: ZDB-GENE-040219-8

Gene Name:toll-like receptor 4b, duplicate a
Gene Symbol: tlr4ba

Previous Names: TIR4.1(1) , tlr4a(1)
Nomenclature History

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GENE EXPRESSION:(current status)

All expression data:	6 figure(s) from 4 publications
Wild Type Stages, Structures:	Blastula:Dome (4.33h-4.66h) to Adult (90d-730d, breeding adult)
	blood, brain ... (all 8)
Curated microarray expression:	GEO  (1)

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MUTANTS AND TARGETED KNOCKDOWNS:

Mutant line(s):   2 genotypes
Allele(s):   fh306, unrec_tlr4ba

Phenotype: (current status)

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GENE PRODUCTS:

Gene Ontology

Ontology	GO Term
Molecular Function	protein binding (more)
Biological Process	innate immune response (more)
Cellular Component	integral to membrane (more)

All GO Terms (8)

Protein Families, Domains and Sites:

InterPro:IPR000157 (1) InterPro:IPR000483 (1) InterPro:IPR001611 (1) InterPro:IPR003591 (1)

PROSITE:PS50104 (1)

Pfam:PF00560 (1) Pfam:PF01582 (1)

Gene Product Description

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SEGMENT (CLONE AND PROBE) RELATIONSHIPS:

tlr4ba Contained in

[BAC] CH211-198A12 (1)    (order this)

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SEQUENCE INFORMATION:

Type	Accession #	Length (bp/aa)	Analysis
RNA	RefSeq:NM_001131051 (1)	2328 bp	- Select Tool - ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:BX908770 (1)	126240 bp	- Select Tool - MegaBLAST Ensembl
Polypeptide	UniProtKB:B8A689 (1)	787 aa	- Select Tool - ZFIN BLAST Ensembl SIB BLAST
Sequence Clusters	UniGene:89708 (1)
All Sequence Information (12)

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OTHER  tlr4ba  GENE / MARKER PAGES:

Entrez Gene:403131 (1)

VEGA:OTTDARG00000020691 (1)

Ensembl(Zv8):ENSDARG00000019742 (1)

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MAPPING INFORMATION:

LG:  13  Details

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ORTHOLOGY:

None submitted.

Orthology Note

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Orthology Note for tlr4ba

Orthology with AA evidence from Jault C et al (Mol Immunol 40(11), 759-771; ZDB-PUB-040109-34) was deleted in light of data in Sullivan C et al (ZDB-PUB-091023-26). The authors state: "The strong conclusion from the analysis of conserved syntenies is that the zebrafish genes called tlr4a and tlr4b are not orthologs of the human TLR4 gene, but represent a reciprocal loss of ohnologs derived from the second round of genome duplication at about the time of the vertebrate radiation. The implication of orthology can be avoided where none exists by calling the zebrafish genes tlr4ba and tlr4bb, and the human gene TLR4A.

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CITATIONS   (15)