Gene
jam2a
- ID
- ZDB-GENE-031204-3
- Name
- junctional adhesion molecule 2a
- Symbol
- jam2a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Enables protein heterodimerization activity. Involved in regulation of skeletal muscle fiber development. Acts upstream of or within with a positive effect on myoblast fusion. Acts upstream of or within hematopoietic or lymphoid organ development. Predicted to be located in bicellular tight junction and membrane. Predicted to be part of protein complex involved in cell adhesion. Predicted to be active in cell surface; plasma membrane; and tight junction. Is expressed in several structures, including blood vessel; musculature system; myoblast; nervous system; and pectoral fin bud. Human ortholog(s) of this gene implicated in basal ganglia calcification. Orthologous to human JAM2 (junctional adhesion molecule 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb1002 (11 images)
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Basal ganglia calcification, idiopathic, 8, autosomal recessive | 618824 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003598 | Immunoglobulin subtype 2 |
| Domain | IPR003599 | Immunoglobulin domain subtype |
| Domain | IPR007110 | Immunoglobulin-like domain |
| Domain | IPR013106 | Immunoglobulin V-set domain |
| Family | IPR042625 | Junctional adhesion molecule B |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR036179 | Immunoglobulin-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Immunoglobulin domain subtype | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype 2 | Immunoglobulin V-set domain | Junctional adhesion molecule B |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A4JYM3
|
307 |
Interactions and Pathways
No data available
Plasmids