Gene
hipk2
- ID
- ZDB-GENE-031125-4
- Name
- homeodomain interacting protein kinase 2
- Symbol
- hipk2 Nomenclature History
- Previous Names
-
- cb1009 (1)
- si:dkey-16j24.2
- wu:fk56d12
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to enable SMAD binding activity; protein kinase activity; and transcription corepressor activity. Predicted to contribute to transcription coactivator activity. Acts upstream of or within convergent extension and regulation of melanocyte differentiation. Predicted to be active in cytoplasm and nucleus. Predicted to colocalize with PML body. Is expressed in notochord. Orthologous to human HIPK2 (homeodomain interacting protein kinase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb1009 (11 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa23244 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa23245 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa36590 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa39193 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-hipk2 | N/A | (3) |
| MO2-hipk2 | N/A | (2) |
| MO3-hipk2 | N/A | Shimizu et al., 2014 |
| MO4-hipk2 | N/A | Shimizu et al., 2014 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Family | IPR050494 | Serine/threonine and dual-specificity kinase |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
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Domain Details Per Protein
| Protein | Length | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine and dual-specificity kinase | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2B5G3
|
1197 | |||||
|
UniProtKB:F1Q4N0
|
1228 | |||||
|
UniProtKB:A0A8M2B5J6
|
1227 | |||||
|
UniProtKB:A0A8M2B5G0
|
1196 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-64P10 | ZFIN Curated Data | |
| Contained in | BAC | CH211-1E14 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-16J24 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-239K7 | ZFIN Curated Data | |
| Encodes | EST | cb1009 | Thisse et al., 2001 | |
| Encodes | EST | fk56d12 | ||
| Encodes | cDNA | MGC:198433 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001099985 (1) | 4024 nt | ||
| Genomic | GenBank:BX247877 (1) | 189537 nt | ||
| Polypeptide | UniProtKB:F1Q4N0 (1) | 1228 aa |
- Gonçalves-Carneiro, D., Takata, M.A., Ong, H., Shilton, A., Bieniasz, P.D. (2021) Origin and evolution of the zinc finger antiviral protein. PLoS pathogens. 17:e1009545
- Klingbeil, K., Nguyen, T., Fahrner, A., Guthmann, C., Wang, H., Schoels, M., Lilienkamp, M., Franz, H., Eckert, P., Walz, G., Yakulov, T.A. (2021) Corpuscles of Stannius development requires FGF signaling. Developmental Biology. 481:160-171
- Dooley, C.M., Wali, N., Sealy, I.M., White, R.J., Stemple, D.L., Collins, J.E., Busch-Nentwich, E.M. (2019) The gene regulatory basis of genetic compensation during neural crest induction. PLoS Genetics. 15:e1008213
- Qiu, W., Chen, B., Greer, J., Magnuson, J., Xiong, Y., Zhong, H., Andrzejczyk, N.E., Zheng, C., Schlenk, D. (2019) Transcriptomic responses of Bisphenol S predict involvement of immune function in the cardiotoxicity of early life stage zebrafish (Danio rerio). Environmental science & technology. 54(5):2869-2877
- Mayrhofer, M., Gourain, V., Reischl, M., Affaticati, P., Jenett, A., Joly, J.S., Benelli, M., Demichelis, F., Poliani, P.L., Sieger, D., Mione, M. (2017) A novel brain tumour model in zebrafish reveals the role of YAP activation in MAPK/PI3K induced malignant growth. Disease models & mechanisms. 10(1):15-28
- Shimizu, N., Ishitani, S., Sato, A., Shibuya, H., Ishitani, T. (2014) Hipk2 and PP1c Cooperate to Maintain Dvl Protein Levels Required for Wnt Signal Transduction. Cell Reports. 8(5):1391-404
- Bitomsky, N., Conrad, E., Moritz, C., Polonio-Vallon, T., Sombroek, D., Schultheiss, K., Glas, C., Greiner, V., Herbel, C., Mantovani, F., Del Sal, G., Peri, F., and Hofmann, T.G. (2013) Autophosphorylation and Pin1 binding coordinate DNA damage-induced HIPK2 activation and cell death. Proceedings of the National Academy of Sciences of the United States of America. 110(45):E4203-4212
- Liang, H., Fekete, D.M., and Andrisani, O. (2011) CtBP2 Downregulation during Neural Crest Specification Induces Expression of Mitf and REST, Resulting in Melanocyte Differentiation and Sympathoadrenal Lineage Suppression. Molecular and cellular biology. 31(5):955-970
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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