Gene
ntf3
- ID
- ZDB-GENE-031118-66
- Name
- neurotrophin 3
- Symbol
- ntf3 Nomenclature History
- Previous Names
-
- NT-3 (1)
- ntf3-pen
- wu:fl98d04
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to have growth factor activity. Involved in negative regulation of programmed cell death and peripheral nervous system development. Predicted to localize to several cellular components, including axon; dendrite; and synaptic vesicle. Human ortholog(s) of this gene implicated in Alzheimer's disease and asthma. Is expressed in several structures, including brain; cardiovascular system; otic placode; pancreas primordium; and retina. Orthologous to human NTF3 (neurotrophin 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
la024627Tg | Transgenic insertion | Unknown | Unknown | DNA | |
sa11980 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa38419 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Length | Cystine-knot cytokine | Nerve growth factor conserved site | Nerve growth factor-like | Nerve growth factor-related | Neurotrophin-3 | Neutrophin-3, N-terminal |
---|---|---|---|---|---|---|---|
UniProtKB:A0A8M1P3S4
|
256 |
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Interactions and Pathways
No data available
Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
---|---|---|---|---|---|---|---|
Ab1-ntf3 | polyclonal | IgG | Rabbit |
|
Thermo Fisher Scientific (Lab Vision)
|
2 |
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Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-60D22 | ZFIN Curated Data | |
Encodes | EST | fl98d04 |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001327813 (1) | 1065 nt | ||
Genomic | GenBank:CU468826 (1) | 180804 nt | ||
Polypeptide | UniProtKB:A0A8M1P3S4 (1) | 256 aa |
- Omar, N.A., Kumar, J., Teoh, S.L. (2023) Neuroprotective effects of Neurotrophin-3 in MPTP-induced zebrafish Parkinson's disease model. Frontiers in pharmacology. 14:13074471307447
- Cacialli, P., Lucini, C. (2022) Analysis of the Expression of Neurotrophins and Their Receptors in Adult Zebrafish Kidney. Veterinary sciences. 9(6)
- Hui, S.P., Sugimoto, K., Sheng, D.Z., Kikuchi, K. (2022) Regulatory T cells regulate blastemal proliferation during zebrafish caudal fin regeneration. Frontiers in immunology. 13:981000
- Barui, A.K., Jhelum, P., Nethi, S.K., Das, T., Bhattacharya, D., B, V., Karri, S., Chakravarty, S., Patra, C.R. (2020) Potential Therapeutic Application of Zinc Oxide Nanoflowers in the Cerebral Ischemia Rat Model through Neuritogenic and Neuroprotective Properties. Bioconjugate Chemistry. 31:895-906
- Das, T., Soren, K., Yerasi, M., Kamle, A., Kumar, A., Chakravarty, S. (2020) Molecular Basis of Sex Difference in Neuroprotection induced by Hypoxia Preconditioning in Zebrafish. Molecular neurobiology. 57(12):5177-5192
- Nittoli, V., Sepe, R.M., Coppola, U., D'Agostino, Y., De Felice, E., Palladino, A., Vassalli, Q.A., Locascio, A., Ristoratore, F., Spagnuolo, A., D'Aniello, S., Sordino, P. (2018) A comprehensive analysis of neurotrophins and neurotrophin tyrosine kinase receptors expression during development of zebrafish. The Journal of comparative neurology. 526(6):1057-1072
- Bower, N.I., Koltowska, K., Pichol-Thievend, C., Virshup, I., Paterson, S., Lagendijk, A.K., Wang, W., Lindsey, B.W., Bent, S.J., Baek, S., Rondon-Galeano, M., Hurley, D.G., Mochizuki, N., Simons, C., Francois, M., Wells, C.A., Kaslin, J., Hogan, B.M. (2017) Mural lymphatic endothelial cells regulate meningeal angiogenesis in the zebrafish. Nature Neuroscience. 20(6):774-783
- Hui, S.P., Sheng, D.Z., Sugimoto, K., Gonzalez-Rajal, A., Nakagawa, S., Hesselson, D., Kikuchi, K. (2017) Zebrafish Regulatory T Cells Mediate Organ-Specific Regenerative Programs. Developmental Cell. 43:659-672.e5
- Joshi, P.C., Samineni, R., Bhattacharya, D., Reddy, B.R., Veeraval, L., Das, T., Maitra, S., Wahul, A.B., Karri, S., Pabbaraja, S., Mehta, G., Kumar, A., Chakravarty, S. (2017) A 2-oxa-spiro[5.4]decane scaffold displays neurotrophic, neurogenic and anti-neuroinflammatory activities with high potential for development as a versatile CNS therapeutic. Scientific Reports. 7:1492
- Venero Galanternik, M., Castranova, D., Gore, A.V., Blewett, N.H., Jung, H.M., Stratman, A.N., Kirby, M.R., Iben, J., Miller, M.F., Kawakami, K., Maraia, R.J., Weinstein, B.M. (2017) A novel perivascular cell population in the zebrafish brain. eLIFE. 6
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