ZFIN ID: ZDB-GENE-031118-66
Gene Name: neurotrophin 3
Gene Symbol: ntf3    Nomenclature History

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Previous Names: NT-3 (1), ntf3-pen, wu:fl98d04

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 4 Mapping Details/Browsers
Description: Predicted to have growth factor activity and nerve growth factor receptor binding activity. Involved in negative regulation of programmed cell death and peripheral nervous system development. Predicted to localize to several cellular components, including axon; dendrite; and synaptic vesicle. Is expressed in several structures, including brain; cardiovascular system; otic placode; pancreas primordium; and retina. Human ortholog(s) of this gene implicated in Alzheimer's disease and asthma. Orthologous to human NTF3 (neurotrophin 3).
Genome Resources: Alliance (1),  Gene:386825 (1),  Ensembl(GRCz11):ENSDARG00000059043 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la024627Tg Transgenic Insertion Unknown Unknown DNA
sa11980 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa38419 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH ntf3 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH ntf3 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process negative regulation of programmed cell death (more)
    Cellular Component extracellular region (more)
    Molecular Function growth factor activity (more)
    GO Terms (all 23)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ntf3-201 (1)    Ensembl 1070
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-ntf3 polyclonal IgG Rabbit WB Thermo Fisher Scientific (Lab Vision)
    2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ntf3 No data available
    MARKER RELATIONSHIPS
    ntf3 Contained in: [BAC] CH211-60D22 (1)
    ntf3 Encodes: [EST] fl98d04
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001327813 (1)
    Genomic GenBank:CU468826 (1) 180804 nt
    Select Tool
    Polypeptide UniProtKB:Q568T2 (1) 294 aa
    Sequence Information (all 10)
    ORTHOLOGY for ntf3 ( Chr: 4 )
    CITATIONS (28)