Gene
fli1rs
- ID
- ZDB-GENE-031114-3
- Name
- Fli-1 proto-oncogene, ETS transcription factor-related sequence
- Symbol
- fli1rs Nomenclature History
- Previous Names
-
- fli1b
- zgc:5777174
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Acts upstream of or within angiogenesis; regulation of DNA-templated transcription; and vasculogenesis. Predicted to be active in nucleus. Is expressed in endothelial cell; hematopoietic system; mesoderm; and vasculature. Human ortholog(s) of this gene implicated in blood platelet disease; limb ischemia; and thrombocytopenia. Orthologous to human ETV2 (ETS variant transcription factor 2) and FLI1 (Fli-1 proto-oncogene, ETS transcription factor).
- Genome Resources
- Note
-
This gene is similar to Fli-1 proto-oncogene, ETS transcription factor, but analyses indicate that the ancestral gene was duplicated prior to the divergence of ray- and lobe-fin fishes and not the result of the WGD event in the ray-fin fishes, so the gene name has been updated to fli1rs to reflect this relationship.
- Comparative Information
-
- All Expression Data
- 10 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la027761Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa36230 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| tpl50Gt | Transgenic insertion | Intron 1 | Unknown | DNA | |
| tpl95Gt | Transgenic insertion | Unknown | Unknown | DNA |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Bleeding disorder, platelet-type, 21 | 617443 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Ets domain | ETS family | Pointed domain | Sterile alpha motif/pointed domain superfamily | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3B1W4 | InterPro | 467 | ||||||
| UniProtKB:A0A8M3AQV9 | InterPro | 495 | ||||||
| UniProtKB:A0A8M3AID3 | InterPro | 468 | ||||||
| UniProtKB:A0A8M3ATP1 | InterPro | 496 | ||||||
| UniProtKB:Q5MBG6 | InterPro | 458 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-225P5 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:5777174 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001008780 (1) | 2804 nt | ||
| Genomic | GenBank:BX649388 (1) | 177865 nt | ||
| Polypeptide | UniProtKB:A0A8M3ATP1 (1) | 496 aa |
- Zhang, X., Yang, Y., Wei, Y., Zhao, Q., Lou, X. (2022) Blf and drl cluster synergistically regulate cell fate commitment during zebrafish primitive hematopoiesis. Development (Cambridge, England). 149(24)
- Quillien, A., Gilbert, G., Boulet, M., Ethuin, S., Waltzer, L., Vandel, L. (2021) Prmt5 promotes vascular morphogenesis independently of its methyltransferase activity. PLoS Genetics. 17:e1009641
- Kwon, H.B., Mackie, D.I., Bonnavion, R., Mercier, A.L., Helker, C.S.M., Son, T., Guenter, S., Serafin, D.S., Kim, K.W., Offermanns, S., Caron, K.M., Stainier, D.Y.R. (2020) The Orphan G-Protein Coupled Receptor 182 Is a Negative Regulator of Definitive Hematopoiesis through Leukotriene B4 Signaling. ACS pharmacology & translational science. 3:676-689
- Marass, M., Beisaw, A., Gerri, C., Luzzani, F., Fukuda, N., Günther, S., Kuenne, C., Reischauer, S., Stainier, D.Y.R. (2019) Genome-wide strategies reveal target genes of Npas4l associated with vascular development in zebrafish. Development (Cambridge, England). 146(11):
- Grajevskaja, V., Camerota, D., Bellipanni, G., Balciuniene, J., Balciunas, D. (2018) Analysis of a conditional gene trap reveals that tbx5a is required for heart regeneration in zebrafish. PLoS One. 13:e0197293
- Baltrunaite, K., Craig, M.P., Palencia Desai, S., Chaturvedi, P., Pandey, R.N., Hegde, R.S., Sumanas, S. (2017) ETS transcription factors Etv2 and Fli1b are required for tumor angiogenesis. Angiogenesis. 20(3):307-323
- Macaulay, I.C., Svensson, V., Labalette, C., Ferreira, L., Hamey, F., Voet, T., Teichmann, S.A., Cvejic, A. (2016) Single-Cell RNA-Sequencing Reveals a Continuous Spectrum of Differentiation in Hematopoietic Cells. Cell Reports. 14(4):966-77
- Monteiro, R., Pinheiro, P., Joseph, N., Peterkin, T., Koth, J., Repapi, E., Bonkhofer, F., Kirmizitas, A., Patient, R. (2016) Transforming Growth Factor β Drives Hemogenic Endothelium Programming and the Transition to Hematopoietic Stem Cells. Developmental Cell. 38(4):358-70
- Reischauer, S., Stone, O.A., Villasenor, A., Chi, N., Jin, S.W., Martin, M., Lee, M.T., Fukuda, N., Marass, M., Witty, A., Fiddes, I., Kuo, T., Chung, W.S., Salek, S., Lerrigo, R., Alsiö, J., Luo, S., Tworus, D., Augustine, S.M., Mucenieks, S., Nystedt, B., Giraldez, A.J., Schroth, G.P., Andersson, O., Stainier, D.Y. (2016) Cloche is a bHLH-PAS transcription factor that drives haemato-vascular specification. Nature. 535:294-8
- Craig, M.P., Grajevskaja, V., Liao, H.K., Balciuniene, J., Ekker, S.C., Park, J.S., Essner, J.J., Balciunas, D., Sumanas, S. (2015) Etv2 and Fli1b Function Together as Key Regulators of Vasculogenesis and Angiogenesis. Arterioscler. Thromb. Vasc. Biol.. 35(4):865-76
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