Gene
fli1rs
- ID
- ZDB-GENE-031114-3
- Name
- Fli-1 proto-oncogene, ETS transcription factor-related sequence
- Symbol
- fli1rs Nomenclature History
- Previous Names
-
- fli1b
- zgc:5777174
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Acts upstream of or within angiogenesis; regulation of DNA-templated transcription; and vasculogenesis. Predicted to be active in nucleus. Is expressed in endothelial cell; hematopoietic system; mesoderm; and vasculature. Human ortholog(s) of this gene implicated in blood platelet disease; limb ischemia; and thrombocytopenia. Orthologous to human ETV2 (ETS variant transcription factor 2) and FLI1 (Fli-1 proto-oncogene, ETS transcription factor).
- Genome Resources
- Note
-
This gene is similar to Fli-1 proto-oncogene, ETS transcription factor, but analyses indicate that the ancestral gene was duplicated prior to the divergence of ray- and lobe-fin fishes and not the result of the WGD event in the ray-fin fishes, so the gene name has been updated to fli1rs to reflect this relationship.
- Comparative Information
-
- All Expression Data
- 10 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Bleeding disorder, platelet-type, 21 | 617443 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000418 | Ets domain |
| Domain | IPR003118 | Pointed domain |
| Family | IPR046328 | ETS family |
| Homologous_superfamily | IPR013761 | Sterile alpha motif/pointed domain superfamily |
| Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
| Homologous_superfamily | IPR036390 | Winged helix DNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Ets domain | ETS family | Pointed domain | Sterile alpha motif/pointed domain superfamily | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3B1W4 | InterPro | 467 | ||||||
| UniProtKB:A0A8M3AQV9 | InterPro | 495 | ||||||
| UniProtKB:A0A8M3AID3 | InterPro | 468 | ||||||
| UniProtKB:A0A8M3ATP1 | InterPro | 496 | ||||||
| UniProtKB:Q5MBG6 | InterPro | 458 | ||||||
| UniProtKB:A0A8M2B4J8 | InterPro | 457 | ||||||
| UniProtKB:A0A8M2B4K4 | InterPro | 458 | ||||||
| UniProtKB:A0A8M2B528 | InterPro | 486 | ||||||
| UniProtKB:A0A8M2B4J0 | InterPro | 429 |
Interactions and Pathways
No data available
Plasmids