ZFIN is now using GRCz12tu for Genomic Data
Gene
aclya
- ID
- ZDB-GENE-031113-1
- Name
- ATP citrate lyase a
- Symbol
- aclya Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable ATP citrate synthase activity. Predicted to be involved in acetyl-CoA biosynthetic process and fatty acid biosynthetic process. Predicted to act upstream of or within citrate metabolic process and lipid metabolic process. Predicted to be located in mitochondrion. Predicted to be active in cytosol. Is expressed in several structures, including axis; digestive system; nervous system; optic vesicle; and periderm. Orthologous to human ACLY (ATP citrate lyase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb722 (9 images)
- IMAGE:7162954 (8 images)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Sun et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR017440 | ATP-citrate lyase/succinyl-CoA ligase, active site |
| Conserved_site | IPR017866 | Succinyl-CoA synthetase, beta subunit, conserved site |
| Conserved_site | IPR033847 | ATP-citrate lyase/succinyl-CoA ligase, conserved site |
| Domain | IPR003781 | CoA-binding |
| Domain | IPR005811 | ATP-citrate synthase/succinyl-CoA ligase, C-terminal domain |
| Domain | IPR032263 | ATP-citrate synthase, citrate-binding domain |
| Family | IPR002020 | Citrate synthase |
| Family | IPR014608 | ATP-citrate synthase |
| Homologous_superfamily | IPR016102 | Succinyl-CoA synthetase-like |
| Homologous_superfamily | IPR016142 | Citrate synthase-like, large alpha subdomain |
| Homologous_superfamily | IPR016143 | Citrate synthase-like, small alpha subdomain |
| Homologous_superfamily | IPR036291 | NAD(P)-binding domain superfamily |
| Homologous_superfamily | IPR036969 | Citrate synthase superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | ATP-citrate lyase/succinyl-CoA ligase, active site | ATP-citrate lyase/succinyl-CoA ligase, conserved site | ATP-citrate synthase | ATP-citrate synthase, citrate-binding domain | ATP-citrate synthase/succinyl-CoA ligase, C-terminal domain | Citrate synthase | Citrate synthase-like, large alpha subdomain | Citrate synthase-like, small alpha subdomain | Citrate synthase superfamily | CoA-binding | NAD(P)-binding domain superfamily | Succinyl-CoA synthetase, beta subunit, conserved site | Succinyl-CoA synthetase-like |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6DG67 | InterPro | 1092 | |||||||||||||
| UniProtKB:A0A8M1N0U7 | InterPro | 1092 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers