Gene

fen1

ID
ZDB-GENE-031112-11
Name
flap structure-specific endonuclease 1
Symbol
fen1 Nomenclature History
Previous Names
  • cb879 (1)
Type
protein_coding_gene
Location
Chr: 24 Mapping Details/Browsers
Description
Predicted to have metal ion binding activity and nuclease activity. Involved in retina development in camera-type eye. Predicted to localize to nucleus. Is expressed in brain; head; pectoral fin musculature; and proliferative region. Orthologous to human FEN1 (flap structure-specific endonuclease 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
7 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With fen1 Human Ortholog
No data available
Associated With fen1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR008918 Helix-hairpin-helix motif, class 2
Conserved_site IPR019974 XPG conserved site
Domain IPR006085 XPG, N-terminal
Domain IPR006086 XPG-I domain
Family IPR006084 XPG/Rad2 endonuclease
Family IPR023426 Flap endonuclease 1
Homologous_superfamily IPR029060 PIN-like domain superfamily
Homologous_superfamily IPR036279 5'-3' exonuclease, C-terminal domain superfamily
Domain Details Per Protein
Protein Length 5'-3' exonuclease, C-terminal domain superfamily Flap endonuclease 1 Helix-hairpin-helix motif, class 2 PIN-like domain superfamily XPG conserved site XPG-I domain XPG, N-terminal XPG/Rad2 endonuclease
UniProtKB:Q6TNU4 380
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations