Gene
bub1bb
- ID
- ZDB-GENE-030829-51
- Name
- BUB1 mitotic checkpoint serine/threonine kinase Bb
- Symbol
- bub1bb Nomenclature History
- Previous Names
-
- sb:cb730
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to act upstream of or within mitotic spindle assembly checkpoint signaling. Is expressed in hindbrain; optic tectum; pectoral fin musculature; proliferative region; and retina. Human ortholog(s) of this gene implicated in colorectal cancer and mosaic variegated aneuploidy syndrome 1. Orthologous to human BUB1B (BUB1 mitotic checkpoint serine/threonine kinase B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from Thisse et al., 2001
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb730 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| colorectal cancer | Alliance | Colorectal cancer, somatic | 114500 |
| mosaic variegated aneuploidy syndrome 1 | Alliance | Mosaic variegated aneuploidy syndrome 1 | 257300 |
| [Premature chromatid separation trait] | 176430 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Mad3/Bub1 homology region 1 | Mitotic spindle checkpoint protein Bub1/Mad3 |
|---|---|---|---|
|
UniProtKB:E7F5T9
|
427 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
bub1bb-201
(1)
|
Ensembl | 5,991 nt | ||
| mRNA |
bub1bb-202
(1)
|
Ensembl | 6,078 nt |
Interactions and Pathways
No data available
Plasmids
No data available