Gene
nucb2a
- ID
- ZDB-GENE-030826-14
- Name
- nucleobindin 2a
- Symbol
- nucb2a Nomenclature History
- Previous Names
-
- nucb2
- cb638 (1)
- wu:fa03d10
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable calcium ion binding activity. Acts upstream of or within response to food. Predicted to be located in Golgi apparatus. Predicted to be active in endoplasmic reticulum-Golgi intermediate compartment. Is expressed in several structures, including axial mesoderm; cardiovascular system; digestive system; gonad; and pectoral fin. Orthologous to human NUCB2 (nucleobindin 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 20 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:77669 (21 images)
- cb638 (13 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa16703 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | EF-Hand 1, calcium-binding site | EF-hand domain | EF-hand domain pair | Nucleobindin |
|---|---|---|---|---|---|---|
| UniProtKB:Q7ZUY4 | InterPro | 496 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
nucb2a-201
(1)
|
Ensembl | 2,115 nt | ||
| mRNA |
nucb2a-202
(1)
|
Ensembl | 577 nt | ||
| mRNA |
nucb2a-203
(1)
|
Ensembl | 885 nt | ||
| mRNA |
nucb2a-204
(1)
|
Ensembl | 6,280 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-87H7 | ZFIN Curated Data | |
| Contains | SNP | rs3728045 | ZFIN Curated Data | |
| Contains | SNP | rs3728046 | ZFIN Curated Data | |
| Contains | SNP | rs3728047 | ZFIN Curated Data | |
| Encodes | EST | cb638 | Thisse et al., 2001 | |
| Encodes | EST | fa03d10 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:56328 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77669 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_201493 (1) | 1831 nt | ||
| Genomic | GenBank:BX927397 (1) | 187890 nt | ||
| Polypeptide | UniProtKB:Q7ZUY4 (1) | 496 aa |
- Ahi, E.P., Brunel, M., Tsakoumis, E., Chen, J., Schmitz, M. (2022) Appetite regulating genes in zebrafish gut; a gene expression study. PLoS One. 17:e0255201
- Blanco, A.M., Bertucci, J.I., Hatef, A., Unniappan, S. (2020) Feeding and food availability modulate brain-derived neurotrophic factor, an orexigen with metabolic roles in zebrafish. Scientific Reports. 10:10727
- Blanco, A.M., Bertucci, J.I., Unniappan, S. (2020) FGF21 Mimics a Fasting-Induced Metabolic State and Increases Appetite in Zebrafish. Scientific Reports. 10:6993
- Ahi, E.P., Brunel, M., Tsakoumis, E., Schmitz, M. (2019) Transcriptional study of appetite regulating genes in the brain of zebrafish (Danio rerio) with impaired leptin signalling. Scientific Reports. 9:20166
- Marvel, M.M., Spicer, O.S., Wong, T.T., Zmora, N., Zohar, Y. (2019) Knockout of Gnrh2 in zebrafish (Danio rerio) reveals its roles in regulating feeding behavior and oocyte quality. General and comparative endocrinology. 280:15-23
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Falcinelli, S., Rodiles, A., Hatef, A., Picchietti, S., Cossignani, L., Merrifield, D.L., Unniappan, S., Carnevali, O. (2017) Dietary lipid content reorganizes gut microbiota and probiotic L. rhamnosus attenuates obesity and enhances catabolic hormonal milieu in zebrafish. Scientific Reports. 7:5512
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Falcinelli, S., Rodiles, A., Unniappan, S., Picchietti, S., Gioacchini, G., Merrifield, D.L., Carnevali, O. (2016) Probiotic treatment reduces appetite and glucose level in the zebrafish model. Scientific Reports. 6:18061
- Nair, N., Gerger, C., Hatef, A., Weber, L.P., Unniappan, S. (2016) Ultrasonography Reveals In Vivo Dose-Dependent Inhibition of End Systolic and Diastolic Volumes, Heart Rate and Cardiac Output by Nesfatin-1 in Zebrafish. General and comparative endocrinology. 234:142-50
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