Gene

dlst

ID

ZDB-GENE-030326-1

Name

dihydrolipoamide S-succinyltransferase

Symbol

dlst Nomenclature History

Previous Names

cb60 (1)
schneckentempo (1)
wu:fc39d01

Type

protein_coding_gene

Location

Chr: 17 Mapping Details/Browsers

Description

Predicted to have dihydrolipoyllysine-residue succinyltransferase activity. Involved in several processes, including ATP biosynthetic process; heart contraction; and mitochondrion morphogenesis. Predicted to localize to oxoglutarate dehydrogenase complex. Human ortholog(s) of this gene implicated in Alzheimer's disease and paraganglioma. Is expressed in several structures, including immature eye; musculature system; nervous system; neural plate; and segmental plate. Orthologous to human DLST (dihydrolipoamide S-succinyltransferase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

9 figures from 4 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

cb60 (31 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 7 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With dlst Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Pheochromocytoma/paraganglioma syndrome 7	618475

Associated With dlst Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR003016	2-oxo acid dehydrogenase, lipoyl-binding site
Domain	IPR000089	Biotin/lipoyl attachment
Domain	IPR001078	2-oxoacid dehydrogenase acyltransferase, catalytic domain
Family	IPR006255	Dihydrolipoamide succinyltransferase
Homologous_superfamily	IPR011053	Single hybrid motif
Homologous_superfamily	IPR023213	Chloramphenicol acetyltransferase-like domain superfamily

Domain Details Per Protein

Protein	Length	2-oxoacid dehydrogenase acyltransferase, catalytic domain	2-oxo acid dehydrogenase, lipoyl-binding site	Biotin/lipoyl attachment	Chloramphenicol acetyltransferase-like domain superfamily	Dihydrolipoamide succinyltransferase	Single hybrid motif
UniProtKB:Q7ZVL3 InterPro	458

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	dlst-201 (1) Ensembl	Havana	1889 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	dlst-002 (1) Ensembl	Havana	725 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	dlst-003 (1) Ensembl	Havana	764 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	dlst-004 (1) Ensembl	Havana	706 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations