Gene

alox5ap

ID

ZDB-GENE-030131-9322

Name

arachidonate 5-lipoxygenase-activating protein

Symbol

alox5ap Nomenclature History

Previous Names

Flap (1)
wu:fj65d02
zgc:63982

Type

protein_coding_gene

Location

Chr: 10 Mapping Details/Browsers

Description

Predicted to have glutathione peroxidase activity; glutathione transferase activity; and leukotriene-C4 synthase activity. Involved in angiogenesis. Predicted to localize to endoplasmic reticulum and nuclear envelope. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); asthma; brain infarction (multiple); breast cancer; and cerebral palsy. Orthologous to human ALOX5AP (arachidonate 5-lipoxygenase activating protein).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With alox5ap Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
cerebral infarction	Alliance	{Stroke, susceptibility to}	601367

Associated With alox5ap Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR001129	Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein
Family	IPR001446	5-lipoxygenase-activating protein
Family	IPR050997	Membrane-associated proteins in eicosanoid and glutathione metabolism
Homologous_superfamily	IPR023352	Membrane associated eicosanoid/glutathione metabolism-like domain superfamily