Gene
anxa1a
- ID
- ZDB-GENE-030131-6664
- Name
- annexin A1a
- Symbol
- anxa1a Nomenclature History
- Previous Names
-
- wu:fa01d11
- wu:fa05d11
- wu:fk69h01
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable calcium-dependent phospholipid binding activity and phosphatidylserine binding activity. Acts upstream of or within fin regeneration. Predicted to be located in basolateral plasma membrane and cilium. Predicted to be active in several cellular components, including nucleus; plasma membrane; and vesicle membrane. Is expressed in eye; integument; muscle; periderm; and yolk syncytial layer. Human ortholog(s) of this gene implicated in brain ischemia and pancreatic cancer. Orthologous to human ANXA1 (annexin A1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:64000 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la015618Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa33598 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Annexin | Annexin A1 | Annexin repeat | Annexin repeat, conserved site | Annexin superfamily |
|---|---|---|---|---|---|---|
|
UniProtKB:Q804H2
|
340 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
anxa1a-201
(1)
|
Ensembl | 1,208 nt | ||
| mRNA |
anxa1a-202
(1)
|
Ensembl | 1,206 nt | ||
| mRNA |
anxa1a-205
(1)
|
Ensembl | 805 nt | ||
| ncRNA |
anxa1a-002
(1)
|
Ensembl | 603 nt | ||
| ncRNA |
anxa1a-004
(1)
|
Ensembl | 814 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-229D2 | ZFIN Curated Data | |
| Encodes | EST | fa01d11 | ||
| Encodes | EST | fa05d11 | ||
| Encodes | EST | fk69h01 | ||
| Encodes | cDNA | MGC:64000 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191551 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_181758 (1) | 1235 nt | ||
| Genomic | GenBank:BX296526 (1) | 179086 nt | ||
| Polypeptide | UniProtKB:Q804H2 (1) | 340 aa |
- Bise, T., de Preux Charles, A.S., Jaźwińska, A. (2019) Ciliary neurotrophic factor stimulates cardioprotection and the proliferative activity in the adult zebrafish heart. NPJ Regenerative medicine. 4:2
- Unal Eroglu, A., Mulligan, T.S., Zhang, L., White, D.T., Sengupta, S., Nie, C., Lu, N.Y., Qian, J., Xu, L., Pei, W., Burgess, S.M., Saxena, M.T., Mumm, J.S. (2018) Multiplexed CRISPR/Cas9 Targeting of Genes Implicated in Retinal Regeneration and Degeneration. Frontiers in cell and developmental biology. 6:88
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Ortiz-Villanueva, E., Navarro-Martín, L., Jaumot, J., Benavente, F., Sanz-Nebot, V., Piña, B., Tauler, R. (2017) Metabolic disruption of zebrafish (Danio rerio) embryos by bisphenol A. An integrated metabolomic and transcriptomic approach. Environmental pollution (Barking, Essex : 1987). 231:22-36
- Saxena, S., Purushothaman, S., Meghah, V., Bhatti, B., Poruri, A., Meena Lakshmi, M.G., Sarath Babu, N., Murthy, C.L., Mandal, K.K., Kumar, A., Idris, M.M. (2016) Role of Annexin gene and its regulation during zebrafish caudal fin regeneration. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. 24(3):551-9
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Sreenivasan, R., Jiang, J., Wang, X., Bartfai, R., Kwan, H.Y., Christoffels, A., and Orban, L. (2014) Gonad Differentiation in Zebrafish Is Regulated by the Canonical Wnt Signaling Pathway. Biology of reproduction. 90(2):45
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Roostalu, U., and Strähle, U. (2012) In Vivo imaging of molecular interactions at damaged sarcolemma. Developmental Cell. 22(3):515-529
- Saxena, S., Singh, S.K., Meena Lakshmi, M.G., Meghah, V., Bhatti, B., Brahmendra Swamy, C.V., Sundaram, C.S., and Idris, M.M. (2012) Proteomic analysis of zebrafish caudal fin regeneration. Molecular & cellular proteomics : MCP. 11(6):M111.014118
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