ZFIN ID: ZDB-GENE-030131-6223

Gene Name:suppressor of fused homolog (Drosophila)
Gene Symbol: sufu

Previous Names: wu:fi39e05, Su(fu)(1) , fi39e05, dreumes, dre
Nomenclature History

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GENE EXPRESSION:(current status)

Curated microarray expression:

GEO  (1)

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MUTANTS AND TARGETED KNOCKDOWNS:

Mutant line(s):   1 genotype
Allele(s):   tm146d

Phenotype: (current status)

Data:	4 figures from 4 publications
Observed in:	anatomical system, inner ear, lens, lens development in camera-type eye, sensory system ... (all 7)

Knockdown reagents: MO1-sufu (1) ,   MO2-sufu (1) ,   MO3-sufu (1) ,   MO4-sufu (1)

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GENE PRODUCTS:

Gene Ontology

Ontology	GO Term
Molecular Function	protein binding
Biological Process	negative regulation of smoothened signaling pathway (more)
Cellular Component	Hedgehog signaling complex

All GO Terms (5)

Protein Families, Domains and Sites:

InterPro:IPR007768 (1) InterPro:IPR016591 (1)

Pfam:PF05076 (1)

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SEGMENT (CLONE AND PROBE) RELATIONSHIPS:

sufu Contained in	[BAC] CH211-264D7 (1)    (order this)
sufu Contains	[SNP] rs3728538 (1)
sufu Encodes	[EST] fi39e05 [STS] chunp30108 [cDNA] MGC:55464 (1)    (order this) , MGC:175081 (1)    (order this) , MGC:193047 (1)    (order this)

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SEQUENCE INFORMATION:

Type	Accession #	Length (bp/aa)	Analysis
RNA	RefSeq:NM_201309 (1)	2764 bp	- Select Tool - ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:BX284670 (1)	159822 bp	- Select Tool - MegaBLAST Ensembl
Polypeptide	UniProtKB:Q7ZVZ9 (1)	485 aa	- Select Tool - ZFIN BLAST Ensembl SIB BLAST
Sequence Clusters	UniGene:150643 (1)
All Sequence Information (15)

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OTHER  sufu  GENE / MARKER PAGES:

Entrez Gene:100001615 (1)

Ensembl(Zv8):ENSDARG00000056801 (1)

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MAPPING INFORMATION:

LG:  13  Details

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ORTHOLOGY:

				Evidence
Species	Symbol	Chromosome (Position)	Accession #	AA	CL
Zebrafish	sufu	13
Human	SUFU	10 (q24.32)	OMIM:607035 Entrez Gene:51684
Mouse	Sufu	19 (47.00 cM)	MGI:1345643 Entrez Gene:24069
Fruit fly	Su(fu)	3R	FLYBASE:FBgn0005355 Entrez Gene:41565
Orthology Details

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CITATIONS   (23)