Gene

sufu

ID
ZDB-GENE-030131-6223
Name
suppressor of fused homolog (Drosophila)
Symbol
sufu Nomenclature History
Previous Names
  • Su(fu) (1)
  • dre
  • dreumes
  • fi39e05
  • sb:eu762
  • wu:fi39e05
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Exhibits zinc ion binding activity. Involved in several processes, including lens development in camera-type eye; negative regulation of smoothened signaling pathway; and smoothened signaling pathway. Localizes to Hedgehog signaling complex. Human ortholog(s) of this gene implicated in Joubert syndrome 32; familial meningioma; medulloblastoma; and nevoid basal cell carcinoma syndrome. Orthologous to human SUFU (SUFU negative regulator of hedgehog signaling).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
4 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
17 figures from 12 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With sufu Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Joubert syndrome 32 Alliance Joubert syndrome 32 617757
medulloblastoma Alliance {Medulloblastoma} 155255
nevoid basal cell carcinoma syndrome 2 Alliance Basal cell nevus syndrome 2 620343
{Meningioma, familial, susceptibility to} 607174
Associated With sufu Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR020941 Suppressor of fused-like domain
Domain IPR024314 Suppressor of fused C-terminal
Family IPR007768 Suppressor of fused
Family IPR016591 Suppressor of fused, eukaryotic
Homologous_superfamily IPR037181 Suppressor of fused, N-terminal
Homologous_superfamily IPR038489 Suppressor of fused, C-terminal domain superfamily
Domain Details Per Protein
Protein Length Suppressor of fused Suppressor of fused C-terminal Suppressor of fused, C-terminal domain superfamily Suppressor of fused, eukaryotic Suppressor of fused-like domain Suppressor of fused, N-terminal
UniProtKB:Q7ZVZ9 485
UniProtKB:A9JRW8 472
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-sufu monoclonal Mouse
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations