ZFIN ID: ZDB-GENE-030131-6223
Gene Name: suppressor of fused homolog (Drosophila)
Gene Symbol: sufu    Nomenclature History

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Previous Names: Su(fu) (1), dre, dreumes, fi39e05, sb:eu762, wu:fi39e05

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Exhibits zinc ion binding activity. Involved in several processes, including lens development in camera-type eye; negative regulation of smoothened signaling pathway; and smoothened signaling pathway. Localizes to Hedgehog signaling complex. Human ortholog(s) of this gene implicated in Joubert syndrome 32; familial meningioma; medulloblastoma; and nevoid basal cell carcinoma syndrome. Orthologous to human SUFU (SUFU negative regulator of hedgehog signaling).
Genome Resources: Alliance (1),  Gene:100001615 (1),  Ensembl(GRCz11):ENSDARG00000056801 (2)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2005 [eu762]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
tm146d Point Mutation Exon 3 Missense ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-sufu N/A 4
    MO2-sufu N/A 4
    MO3-sufu N/A 4
    MO4-sufu N/A 2
    MO5-sufu N/A 1
    DISEASE ASSOCIATED WITH sufu HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Joubert syndrome 32 Alliance Joubert syndrome 32 617757
    medulloblastoma Alliance Medulloblastoma, desmoplastic 155255
    nevoid basal cell carcinoma syndrome Alliance Basal cell nevus syndrome 109400
    {Meningioma, familial, susceptibility to} 607174
    DISEASE ASSOCIATED WITH sufu VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process negative regulation of smoothened signaling pathway (more)
    Cellular Component Hedgehog signaling complex (more)
    Molecular Function zinc ion binding (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    aberrant processed transcript sufu-205 (1)    Ensembl 724
    mRNA sufu-201 (1)    Ensembl 2748
    sufu-204 (1)    Ensembl 2748
    ncRNA sufu-004 (1)    Ensembl 976
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-sufu monoclonal Mouse 1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM sufu No data available
    MARKER RELATIONSHIPS
    sufu Contained in: [BAC] CH211-195E19 (1), CH211-264D7 (1), DKEY-261G4 (1) (order this)
    sufu Contains: [SNP] rs3728538 (1)
    sufu Encodes: [EST] eu762 (1), fi39e05, tdsubc_2a6
    [STS] chunp30108
    [cDNA] MGC:55464 (1), MGC:175081 (1), MGC:193047 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_201309 (1) 2764 nt
    Genomic GenBank:CR559945 (1) 186151 nt
    Select Tool
    Polypeptide UniProtKB:A0A0R4IN62 (1) 485 aa
    Sequence Information (all 30)
    ORTHOLOGY for sufu ( Chr: 13 )
    CITATIONS (50)