Gene

sufu

ID
ZDB-GENE-030131-6223
Name
suppressor of fused homolog (Drosophila)
Symbol
sufu Nomenclature History
Previous Names
  • Su(fu) (1)
  • dre
  • dreumes
  • fi39e05
  • sb:eu762
  • wu:fi39e05
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Exhibits zinc ion binding activity. Involved in several processes, including lens development in camera-type eye; negative regulation of smoothened signaling pathway; and smoothened signaling pathway. Localizes to Hedgehog signaling complex. Human ortholog(s) of this gene implicated in Joubert syndrome 32; familial meningioma; medulloblastoma; and nevoid basal cell carcinoma syndrome. Orthologous to human SUFU (SUFU negative regulator of hedgehog signaling).
Genome Resources
Note
None
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
17 figures from 12 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With sufu Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Joubert syndrome 32 Alliance Joubert syndrome 32 617757
medulloblastoma Alliance Medulloblastoma, desmoplastic 155255
nevoid basal cell carcinoma syndrome Alliance Basal cell nevus syndrome 109400
{Meningioma, familial, susceptibility to} 607174
Associated With sufu Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR020941 Suppressor of fused-like domain
Domain IPR024314 Suppressor of fused C-terminal
Family IPR007768 Suppressor of fused
Family IPR016591 Suppressor of fused, eukaryotic
Homologous_superfamily IPR037181 Suppressor of fused, N-terminal
Homologous_superfamily IPR038489 Suppressor of fused, C-terminal domain superfamily
Domain Details Per Protein
Protein Length Suppressor of fused Suppressor of fused C-terminal Suppressor of fused, C-terminal domain superfamily Suppressor of fused, eukaryotic Suppressor of fused-like domain Suppressor of fused, N-terminal
UniProtKB:A0A0R4IFN6 50
UniProtKB:A9JRW8 472
UniProtKB:Q7ZVZ9 485
UniProtKB:A0A0R4IN62 485
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-sufu monoclonal Mouse
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations