Gene

rnf146

ID

ZDB-GENE-030131-5997

Name

ring finger protein 146

Symbol

rnf146 Nomenclature History

Previous Names

wu:fi29e08

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Description

Predicted to enable poly-ADP-D-ribose binding activity and ubiquitin-protein transferase activity. Predicted to be involved in positive regulation of canonical Wnt signaling pathway; protein ubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within Wnt signaling pathway. Predicted to be located in cytosol. Predicted to be active in cytoplasm and nucleus. Is expressed in female organism. Orthologous to human RNF146 (ring finger protein 146).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Newman et al., 2019

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With rnf146 Human Ortholog

No data available

Associated With rnf146 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017907	Zinc finger, RING-type, conserved site
Domain	IPR001841	Zinc finger, RING-type
Domain	IPR004170	WWE domain
Domain	IPR018123	WWE domain, subgroup
Domain	IPR044110	RNF146, RING finger, HC subclass
Family	IPR033509	E3 ubiquitin-protein ligase RNF146
Homologous_superfamily	IPR013083	Zinc finger, RING/FYVE/PHD-type
Homologous_superfamily	IPR037197	WWE domain superfamily

Domain Details Per Protein

Protein	Length	E3 ubiquitin-protein ligase RNF146	RNF146, RING finger, HC subclass	WWE domain	WWE domain, subgroup	WWE domain superfamily	Zinc finger, RING/FYVE/PHD-type	Zinc finger, RING-type	Zinc finger, RING-type, conserved site
UniProtKB:F1R5P0 InterPro	364
UniProtKB:Q7ZUK0 InterPro	364

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	rnf146-202 (1) Ensembl	Ensembl	4,004 nt	Select Tool ZFIN BLAST
mRNA	rnf146-203 (1) Ensembl	Ensembl	765 nt	Select Tool ZFIN BLAST
mRNA	rnf146-204 (1) Ensembl	Ensembl	2,924 nt	Select Tool ZFIN BLAST
ncRNA	rnf146-003 (1) Ensembl	Ensembl	804 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations