Gene

cul3a

ID

ZDB-GENE-030131-3376

Name

cullin 3a

Symbol

cul3a Nomenclature History

Previous Names

cul3
wu:fc37e01

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Description

Predicted to have ubiquitin protein ligase binding activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Predicted to localize to cullin-RING ubiquitin ligase complex. Human ortholog(s) of this gene implicated in pseudohypoaldosteronism. Orthologous to human CUL3 (cullin 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

MGC:77385 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Edwards et al., 2020
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cul3a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Neurodevelopmental disorder with or without autism or seizures	619239
		Pseudohypoaldosteronism, type IIE	614496

Associated With cul3a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR016157	Cullin, conserved site
Domain	IPR001373	Cullin, N-terminal
Domain	IPR016158	Cullin homology domain
Domain	IPR019559	Cullin protein, neddylation domain
Family	IPR045093	Cullin
Homologous_superfamily	IPR016159	Cullin repeat-like-containing domain superfamily
Homologous_superfamily	IPR036317	Cullin homology domain superfamily
Homologous_superfamily	IPR036388	Winged helix-like DNA-binding domain superfamily
Homologous_superfamily	IPR036390	Winged helix DNA-binding domain superfamily