Gene
vapb
- ID
- ZDB-GENE-030131-2348
- Name
- VAMP (vesicle-associated membrane protein)-associated protein B and C
- Symbol
- vapb Nomenclature History
- Previous Names
-
- fc05d09
- wu:fa96d05
- wu:fc05d09
- zgc:66045 (1)
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable protein-membrane adaptor activity. Acts upstream of or within regulation of heart contraction and swimming behavior. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in endoplasmic reticulum membrane and plasma membrane. Is expressed in atrium; cardiac ventricle; and heart. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 8; autosomal dominant adult-onset proximal spinal muscular atrophy; and spinal muscular atrophy. Orthologous to human VAPB (VAMP associated protein B and C).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-vapb | (2) | |
| CRISPR2-vapb | (2) | |
| MO1-vapb | N/A | (2) |
1 - 3 of 3
Show
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| amyotrophic lateral sclerosis type 8 | Alliance | Amyotrophic lateral sclerosis 8 | 608627 |
| autosomal dominant adult-onset proximal spinal muscular atrophy | Alliance | Spinal muscular atrophy, late-onset, Finkel type | 182980 |
1 - 2 of 2
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Immunoglobulin-like fold | Major sperm protein (MSP) domain | PapD-like superfamily | Vesicle-associated membrane-protein-associated protein |
|---|---|---|---|---|---|
|
UniProtKB:A0A8M9PZG9
|
242 | ||||
|
UniProtKB:Q6P2B0
|
243 |
1 - 2 of 2
Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(-5kbneurod1:vapb-HaloTag) |
|
| 1 | Zebrafish Nomenclature Committee | |
| Tg(-5kbneurod1:vapb_P56S-HaloTag) |
|
| 1 | Zebrafish Nomenclature Committee |
1 - 2 of 2
Show
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-27C11 | ZFIN Curated Data | |
| Encodes | EST | fa96d05 | ZFIN Curated Data | |
| Encodes | EST | fc05d09 | ||
| Encodes | cDNA | MGC:66045 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:173944 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:173945 | ZFIN Curated Data |
1 - 6 of 6
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_212647 (1) | 4126 nt | ||
| Genomic | GenBank:BX629346 (1) | 214213 nt | ||
| Polypeptide | UniProtKB:Q6P2B0 (1) | 243 aa |
- Wong, H.C., Lang, A.E., Stein, C., Drerup, C.M. (2024) ALS-linked VapB P56S mutation alters neuronal mitochondrial turnover at the synapse. The Journal of neuroscience : the official journal of the Society for Neuroscience. 44(35):
- Silbernagel, N., Walecki, M., Schäfer, M.K., Kessler, M., Zobeiri, M., Rinné, S., Kiper, A.K., Komadowski, M.A., Vowinkel, K.S., Wemhöner, K., Fortmüller, L., Schewe, M., Dolga, A.M., Scekic-Zahirovic, J., Matschke, L.A., Culmsee, C., Baukrowitz, T., Monassier, L., Ullrich, N.D., Dupuis, L., Just, S., Budde, T., Fabritz, L., Decher, N. (2018) The VAMP-associated protein VAPB is required for cardiac and neuronal pacemaker channel function. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 32(11):6159-6173
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Miao, L., Yuan, Y., Cheng, F., Fang, J., Zhou, F., Ma, W., Jiang, Y., Huang, X., Wang, Y., Shan, L., Chen, D., Zhang, J. (2017) Translation repression by maternal RNA binding protein zar1 is essential for early oogenesis in zebrafish. Development (Cambridge, England). 144(1):128-138
- Kabashi, E., El Oussini, H., Bercier, V., Gros-Louis, F., Valdmanis, P.N., McDearmid, J., Mejier, I.A., Dion, P.A., Dupre, N., Hollinger, D., Sinniger, J., Dirrig-Grosch, S., Camu, W., Meininger, V., Loeffler, J.P., René, F., Drapeau, P., Rouleau, G.A., and Dupuis, L. (2013) Investigating the contribution of VAPB/ALS8 loss of function in amyotrophic lateral sclerosis. Human molecular genetics. 22(12):2350-60
- Tiefenbach, J., Moll, P.R., Nelson, M.R., Hu, C., Baev, L., Kislinger, T., and Krause, H.M. (2010) A live zebrafish-based screening system for human nuclear receptor ligand and cofactor discovery. PLoS One. 5(3):e9797
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
1 - 7 of 7
Show