Gene

vapb

ID
ZDB-GENE-030131-2348
Name
VAMP (vesicle-associated membrane protein)-associated protein B and C
Symbol
vapb Nomenclature History
Previous Names
  • fc05d09
  • wu:fa96d05
  • wu:fc05d09
  • zgc:66045 (1)
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Predicted to have FFAT motif binding activity. Involved in swimming behavior. Predicted to localize to endoplasmic reticulum membrane and plasma membrane. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 8; autosomal dominant adult-onset proximal spinal muscular atrophy; and spinal muscular atrophy. Is expressed in atrium; cardiac ventricle; and heart. Orthologous to human VAPB (VAMP associated protein B and C).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With vapb Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
amyotrophic lateral sclerosis type 8 Alliance Amyotrophic lateral sclerosis 8 608627
autosomal dominant adult-onset proximal spinal muscular atrophy Alliance Spinal muscular atrophy, late-onset, Finkel type 182980
Associated With vapb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000535 Major sperm protein (MSP) domain
Family IPR016763 Vesicle-associated membrane-protein-associated protein
Homologous_superfamily IPR008962 PapD-like superfamily
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Domain Details Per Protein
Protein Length Immunoglobulin-like fold Major sperm protein (MSP) domain PapD-like superfamily Vesicle-associated membrane-protein-associated protein
UniProtKB:Q6P2B0 243
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-vapb polyclonal Rabbit
  • IHC
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations