Gene
ccn2a
- ID
- ZDB-GENE-030131-102
- Name
- cellular communication network factor 2a
- Symbol
- ccn2a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable heparin binding activity and integrin binding activity. Acts upstream of or within with a negative effect on definitive hemopoiesis. Acts upstream of or within several processes, including cranial skeletal system development; endoderm development; and notochord development. Predicted to be located in cell periphery and extracellular region. Predicted to be active in extracellular matrix and extracellular space. Is expressed in several structures, including digestive system; fin; head; mesoderm; and spinal cord. Human ortholog(s) of this gene implicated in spondyloepimetaphyseal dysplasia, Li-Shao-Li type. Orthologous to human CCN2 (cellular communication network factor 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 44 figures from 28 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu936 (12 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| spondyloepimetaphyseal dysplasia, Li-Shao-Li type | Alliance | ?Spondyloepimetaphyseal dysplasia, Li-Shao-Li type | 621099 |
| Kyphomelic dysplasia | 211350 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| osteochondrodysplasia | WT + CRISPR10-ccn2a + CRISPR11-ccn2a | standard conditions | Singh et al., 2024 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000867 | Insulin-like growth factor-binding protein, IGFBP |
| Domain | IPR001007 | VWFC domain |
| Domain | IPR006207 | Cystine knot, C-terminal |
| Domain | IPR006208 | Glycoprotein hormone subunit beta |
| Domain | IPR043973 | CCN, TSP1 domain |
| Family | IPR012395 | IGFBP-related, CNN |
| Family | IPR050941 | Cellular Communication Network Factor |
| Homologous_superfamily | IPR009030 | Growth factor receptor cysteine-rich domain superfamily |
| Homologous_superfamily | IPR036383 | Thrombospondin type-1 (TSP1) repeat superfamily |
| Repeat | IPR000884 | Thrombospondin type-1 (TSP1) repeat |
Domain Details Per Protein
| Protein | Additional Resources | Length | CCN, TSP1 domain | Cellular Communication Network Factor | Cystine knot, C-terminal | Glycoprotein hormone subunit beta | Growth factor receptor cysteine-rich domain superfamily | IGFBP-related, CNN | Insulin-like growth factor-binding protein, IGFBP | Thrombospondin type-1 (TSP1) repeat | Thrombospondin type-1 (TSP1) repeat superfamily | VWFC domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q5RI33 | InterPro | 345 |
Interactions and Pathways
No data available
Plasmids
No data available