Gene
esr2a
- ID
- ZDB-GENE-030116-2
- Name
- estrogen receptor 2a
- Symbol
- esr2a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Enables estradiol binding activity; nuclear estrogen receptor activity; and steroid hormone binding activity. Acts upstream of or within response to estrogen. Predicted to be active in chromatin and nucleus. Is expressed in several structures, including blastodisc; brain; pelvic fin bud; pleuroperitoneal region; and sensory system. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); bone disease (multiple); hypospadias; and neurodegenerative disease (multiple). Orthologous to human ESR2 (estrogen receptor 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 38 figures from 27 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu81 (1 image)
- bc044349 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ihb295 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| ihb296 | Allele with one insertion | Unknown | Unknown | CRISPR | |
| la021455Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| nv1182 | Allele with one insertion | Unknown | Unknown | CRISPR | |
| sa16405 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa25133 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa37010 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| uab134 | Allele with one deletion | Unknown | Frameshift, Premature Stop | CRISPR | |
| umo11 | Allele with one deletion | Exon 2 | Premature Stop | CRISPR | |
| umo12 | Allele with one deletion | Exon 2 | Premature Stop | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-esr2a | Varshney et al., 2015 | |
| CRISPR2-esr2a | (4) | |
| CRISPR3-esr2a | (2) | |
| CRISPR4-esr2a | (2) | |
| MO1-esr2a | N/A | (5) |
| MO2-esr2a | N/A | (2) |
| MO3-esr2a | N/A | (2) |
| MO4-esr2a | N/A | (3) |
| MO5-esr2a | N/A | Moreman et al., 2018 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| ovarian dysgenesis 8 | Alliance | ?Ovarian dysgenesis 8 | 618187 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000536 | Nuclear hormone receptor, ligand-binding domain |
| Domain | IPR001628 | Zinc finger, nuclear hormone receptor-type |
| Domain | IPR021064 | Estrogen receptor beta-like, N-terminal |
| Family | IPR001723 | Nuclear hormone receptor |
| Family | IPR024178 | Estrogen receptor/oestrogen-related receptor |
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Domain Details Per Protein
| Protein | Length | Estrogen receptor beta/gamma | Estrogen receptor beta-like, N-terminal | Estrogen receptor/oestrogen-related receptor | Nuclear hormone receptor | Nuclear hormone receptor family NR3 subfamily | Nuclear hormone receptor, ligand-binding domain | Nuclear hormone receptor-like domain superfamily | Zinc finger, NHR/GATA-type | Zinc finger, nuclear hormone receptor-type |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q7ZU32
|
553 |
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Interactions and Pathways
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-274C14 | ZFIN Curated Data | |
| Encodes | EST | bc044349 | Bertrand et al., 2007 | |
| Encodes | EST | eu81 | Thisse et al., 2005 | |
| Encodes | EST | fi14h07 | ||
| Encodes | cDNA | MGC:55251 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192492 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_180966 (1) | 3111 nt | ||
| Genomic | GenBank:BX255911 (1) | 206480 nt | ||
| Polypeptide | UniProtKB:Q7ZU32 (1) | 553 aa |
- Ai, N., Han, C.R., Zhao, H., Cheng, S.Y., Ge, W. (2024) Disruption of thyroid hormone receptor thrab leads to female infertility in zebrafish. Endocrinology. 165(5):
- Shaw, K., Lu, C., Liu, X., Trudeau, V.L. (2023) Arginine vasopressin injection rescues delayed oviposition in cyp19a1b-/- mutant female zebrafish. Frontiers in endocrinology. 14:13086751308675
- Wesselman, H.M., Gatz, A.E., Pfaff, M.R., Arceri, L., Wingert, R.A. (2023) Estrogen Signaling Influences Nephron Segmentation of the Zebrafish Embryonic Kidney. Cells. 12(4):
- Zhai, Y., Zhang, X., Zhao, C., Geng, R., Wu, K., Yuan, M., Ai, N., Ge, W. (2023) Rescue of bmp15 deficiency in zebrafish by mutation of inha reveals mechanisms of BMP15 regulation of folliculogenesis. PLoS Genetics. 19:e1010954e1010954
- Li, X., Wang, L., Qin, X., Chen, X., Li, L., Huang, Z., Zhang, W., Liu, W. (2022) Estrogens revert neutrophil hyperplasia by inhibiting Hif1α-cMyb pathway in zebrafish myelodysplastic syndromes models. Cell death discovery. 8:323
- Liu, Y., Kassack, M.E., McFaul, M.E., Christensen, L.N., Siebert, S., Wyatt, S.R., Kamei, C.N., Horst, S., Arroyo, N., Drummond, I.A., Juliano, C.E., Draper, B.W. (2022) Single-cell transcriptome reveals insights into the development and function of the zebrafish ovary. eLIFE. 11:
- Tsakoumis, E., Ahi, E.P., Schmitz, M. (2022) Impaired leptin signaling causes subfertility in female zebrafish. Molecular and Cellular Endocrinology. 546:111595
- Zhao, C., Zhai, Y., Geng, R., Wu, K., Song, W., Ai, N., Ge, W. (2022) Genetic analysis of activin/inhibin β subunits in zebrafish development and reproduction. PLoS Genetics. 18:e1010523e1010523
- Biswas, S., Maitra, S. (2021) Altered redox homeostasis in steroid-depleted follicles attenuates hCG regulation of follicular events: Cross-talk between endocrine and IGF axis in maturing oocytes. Free radical biology & medicine. 172:675-687
- Liu, X., Xie, X., Liu, H. (2021) Effects of Diethylstilbestrol on Zebrafish Gonad Development and Endocrine Disruption Mechanism. Biomolecules. 11(7):
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