Gene
esr2a
- ID
- ZDB-GENE-030116-2
- Name
- estrogen receptor 2a
- Symbol
- esr2a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Exhibits estrogen receptor activity; nuclear receptor activity; and steroid hormone binding activity. Involved in response to estrogen. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); arthritis (multiple); autoimmune hypersensitivity disease (multiple); hypospadias; and neurodegenerative disease (multiple). Is expressed in several structures, including blastodisc; brain; pelvic fin bud; pleuroperitoneal region; and sensory system. Orthologous to human ESR2 (estrogen receptor 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 38 figures from 27 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu81 (1 image)
- bc044349 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| ovarian dysgenesis 8 | Alliance | ?Ovarian dysgenesis 8 | 618187 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000536 | Nuclear hormone receptor, ligand-binding domain |
| Domain | IPR001628 | Zinc finger, nuclear hormone receptor-type |
| Domain | IPR021064 | Estrogen receptor beta-like, N-terminal |
| Family | IPR001723 | Nuclear hormone receptor |
| Family | IPR024178 | Estrogen receptor/oestrogen-related receptor |
| Family | IPR028355 | Estrogen receptor beta/gamma |
| Homologous_superfamily | IPR013088 | Zinc finger, NHR/GATA-type |
| Homologous_superfamily | IPR035500 | Nuclear hormone receptor-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Estrogen receptor beta/gamma | Estrogen receptor beta-like, N-terminal | Estrogen receptor/oestrogen-related receptor | Nuclear hormone receptor | Nuclear hormone receptor, ligand-binding domain | Nuclear hormone receptor-like domain superfamily | Zinc finger, NHR/GATA-type | Zinc finger, nuclear hormone receptor-type |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q7ZU32
|
553 |
Interactions and Pathways
Plasmids
No data available