Gene
bcl2l1
- ID
- ZDB-GENE-010730-1
- Name
- BCL2 like 1
- Symbol
- bcl2l1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Exhibits cysteine-type endopeptidase inhibitor activity involved in apoptotic process. Involved in negative regulation of apoptotic process; thyroid gland development; and tissue homeostasis. Predicted to localize to mitochondrial outer membrane. Human ortholog(s) of this gene implicated in breast cancer; carcinoma (multiple); leukemia (multiple); and pancreatic cancer. Is expressed in several structures, including blood island; endocrine system; extension; immune system; and nervous system. Orthologous to human BCL2L1 (BCL2 like 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 24 figures from 16 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb1021 (10 images)
- IMAGE:6910760 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Porreca et al., 2012
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR020717 | Apoptosis regulator, Bcl-2, BH1 motif, conserved site |
Domain | IPR003093 | Apoptosis regulator, Bcl-2 protein, BH4 |
Domain | IPR046371 | Bcl-2, Bcl-2 homology region 1-3 |
Family | IPR002475 | Bcl2-like |
Family | IPR013279 | Apoptosis regulator, Bcl-X |
Family | IPR026298 | Bcl-2 family |
Homologous_superfamily | IPR036834 | Bcl-2-like superfamily |
Domain Details Per Protein
Protein | Length | Apoptosis regulator, Bcl-2, BH1 motif, conserved site | Apoptosis regulator, Bcl-2 protein, BH4 | Apoptosis regulator, Bcl-X | Bcl-2, Bcl-2 homology region 1-3 | Bcl-2 family | Bcl2-like | Bcl-2-like superfamily |
---|---|---|---|---|---|---|---|---|
UniProtKB:Q90Z98
|
238 |
Type | Name | Annotation Method | Length (nt) | Analysis |
---|---|---|---|---|
mRNA |
bcl2l1-201
(1)
|
Havana | 2025 nt | |
mRNA |
bcl2l1-202
(1)
|
Havana | 1979 nt |
Interactions and Pathways
No data available
Plasmids
No data available