Gene

igf1

ID

ZDB-GENE-010607-2

Name

insulin-like growth factor 1

Symbol

igf1 Nomenclature History

Previous Names

IGF-1a (1)
IGF-I (1)
igf1a (1)

Type

protein_coding_gene

Location

Chr: 4 Mapping Details/Browsers

Description

Enables insulin-like growth factor receptor binding activity. Acts upstream of or within dorsal/ventral pattern formation and positive regulation of cell population proliferation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including digestive system; eye; female organism; musculature system; and solid lens vesicle. Human ortholog(s) of this gene implicated in several diseases, including acne; artery disease (multiple); diabetes mellitus (multiple); myopia; and neurodegenerative disease (multiple). Orthologous to human IGF1 (insulin like growth factor 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

58 figures from 49 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu524 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 9 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With igf1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Insulin-like growth factor I deficiency	608747

Associated With igf1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR022353	Insulin, conserved site
Domain	IPR016179	Insulin-like
Family	IPR022341	Insulin-like growth factor I
Family	IPR022350	Insulin-like growth factor
Family	IPR022352	Insulin family
Homologous_superfamily	IPR036438	Insulin-like superfamily