Gene
cldn3c
- ID
- ZDB-GENE-010328-8
- Name
- claudin 3c
- Symbol
- cldn3c Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable structural molecule activity. Acts upstream of or within several processes, including epithelial cell differentiation; neural retina development; and sensory perception of sound. Predicted to be located in anchoring junction and membrane. Predicted to be active in bicellular tight junction and plasma membrane. Is expressed in several structures, including brain; integument; pleuroperitoneal region; prechordal plate; and sensory system. Orthologous to human CLDN3 (claudin 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 33 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:64049 (11 images)
Wild Type Expression Summary
- All Phenotype Data
- 17 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-cldn3c | Jin et al., 2019 | |
| CRISPR2-cldn3c | Gong et al., 2021 | |
| MO1-cldn3c | N/A | Jin et al., 2019 |
| MO2-cldn3c | N/A | Lu et al., 2020 |
| MO3-cldn3c | N/A | Lu et al., 2020 |
| MO4-cldn3c | N/A | Gong et al., 2021 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Claudin | Claudin-3 | Claudin, conserved site | PMP-22/EMP/MP20/Claudin |
|---|---|---|---|---|---|
|
UniProtKB:Q90XR0
|
214 |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-cldn3c | polyclonal | Rabbit |
|
1 | |||
| Ab2-cldn3 | monoclonal | IgG2b | Mouse |
|
Novus Biologicals, LLC
|
2 |
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Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(cldn3c:DsRedx) |
|
| 1 | Lin et al., 2019 | |
| Tg(cldn3c:GFP) |
|
| 1 | Lin et al., 2019 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-17E16 | ZFIN Curated Data | |
| Encodes | EST | fc56d05 | ZFIN Curated Data | |
| Encodes | EST | fc56g03 | Rauch et al., 2003 | |
| Encodes | cDNA | MGC:64049 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192202 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131767 (1) | 1880 nt | ||
| Genomic | GenBank:CR388166 (1) | 220882 nt | ||
| Polypeptide | UniProtKB:Q90XR0 (1) | 214 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | CLDN3 | 7 | Amino acid sequence comparison (1) |
- Gong, J., Qian, P., Hu, Y., Guo, C., Wei, G., Wang, C., Cai, C., Wang, H., Liu, D. (2021) Claudin h Is Essential for Hair Cell Morphogenesis and Auditory Function in Zebrafish. Frontiers in cell and developmental biology. 9:663995
- Zhang, X.H., Zhou, C.C., Li, C.Y., Hua, Y., Li, K., Wei, P., He, M.F. (2021) Isoliquiritin exert protective effect on telencephalon infarction injury by regulating multi-pathways in zebrafish model of ischemic stroke. Phytomedicine : international journal of phytotherapy and phytopharmacology. 83:153469
- Ferrero, G., Gomez, E., Iyer, S., Rovira, M., Miserocchi, M., Langenau, D.M., Bertrand, J.Y., Wittamer, V. (2020) The macrophage-expressed gene (mpeg) 1 identifies a subpopulation of B cells in the adult zebrafish. Journal of Leukocyte Biology. 107(3):431-443
- Lu, J., Liu, R., Miao, A., Chen, X., Xiao, W., Wang, Y., Cao, D., Pan, J., Li, L., Luo, Y. (2020) The role of cldnh during the early retinal development in zebrafish. Experimental Eye Research. 200:108207
- Solis, C.J., Hamilton, M.K., Caruffo, M., Garcia-Lopez, J.P., Navarrete, P., Guillemin, K., Feijoo, C.G. (2020) Intestinal Inflammation Induced by Soybean Meal Ingestion Increases Intestinal Permeability and Neutrophil Turnover Independently of Microbiota in Zebrafish. Frontiers in immunology. 11:1330
- Jin, M., Wang, D., Xu, W., Wang, H., Cao, Y. (2019) Claudin-7b and Claudin-h are required for controlling cilia morphogenesis in the zebrafish kidney. Mechanisms of Development. 161:103595
- Lin, X., Zhou, Q., Zhao, C., Lin, G., Xu, J., Wen, Z. (2019) An Ectoderm-Derived Myeloid-like Cell Population Functions as Antigen Transporters for Langerhans Cells in Zebrafish Epidermis. Developmental Cell. 49(4):605-617.e5
- Wu, N., Xu, X., Wang, B., Li, X.M., Cheng, Y.Y., Li, M., Xia, X.Q., Zhang, Y.A. (2019) Anti-foodborne enteritis effect of galantamine potentially via acetylcholine anti-inflammatory pathway in fish. Fish & shellfish immunology. 97:204-215
- Gao, S., Liu, S., Yao, J., Li, N., Yuan, Z., Zhou, T., Li, Q., Liu, Z. (2017) Genomic organization and evolution of olfactory receptors and trace amine-associated receptors in channel catfish, Ictalurus punctatus. Biochimica et biophysica acta. 1861(3):644-651
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
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