ZFIN is now using GRCz12tu for Genomic Data
Gene
cyp11a1.1
- ID
- ZDB-GENE-010306-1
- Name
- cytochrome P450 family 11 subfamily A member 1, tandem duplicate 1
- Symbol
- cyp11a1.1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable cholesterol monooxygenase (side-chain-cleaving) activity. Acts upstream of or within several processes, including C21-steroid hormone biosynthetic process; determination of heart left/right asymmetry; and positive regulation of microtubule polymerization. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial inner membrane. Is expressed in several structures, including brain; endocrine system; interrenal primordium; male organism; and yolk syncytial layer. Human ortholog(s) of this gene implicated in congenital adrenal hyperplasia and congenital adrenal insufficiency. Orthologous to human CYP11A1 (cytochrome P450 family 11 subfamily A member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 53 figures from 34 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb957 (11 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital adrenal insufficiency | Alliance | Adrenal insufficiency, congenital, with 46XY sex reversal, partial or complete | 613743 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cytochrome P450 | Cytochrome P450, conserved site | Cytochrome P450, E-class, group I | Cytochrome P450, families 11 and 27 | Cytochrome P450 superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q7SYJ6 | InterPro | 509 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cyp11a1-201
(1)
|
Ensembl | 2,185 nt | ||
| mRNA |
cyp11a1-202
(1)
|
Ensembl | 2,235 nt | ||
| mRNA |
cyp11a1-203
(1)
|
Ensembl | 833 nt | ||
| mRNA |
cyp11a1-204
(1)
|
Ensembl | 776 nt | ||
| mRNA |
cyp11a1-205
(1)
|
Ensembl | 884 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers