Gene

ctbp1

ID

ZDB-GENE-010130-1

Name

C-terminal binding protein 1

Symbol

ctbp1 Nomenclature History

Previous Names

CtBP1 (1)
wu:fi43a11

Type

protein_coding_gene

Location

Chr: 14 Mapping Details/Browsers

Description

Predicted to have NAD binding activity and oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Involved in retinoic acid receptor signaling pathway. Orthologous to human CTBP1 (C-terminal binding protein 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:55227 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Delacruz et al., 2019
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ctbp1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Hypotonia, ataxia, developmental delay, and tooth enamel defect syndrome	617915

Associated With ctbp1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR029752	D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1
Conserved_site	IPR029753	D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site
Domain	IPR006139	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
Domain	IPR006140	D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain
Family	IPR043322	C-terminal binding protein
Family	IPR051638	C-terminal-binding dehydrogenase
Homologous_superfamily	IPR036291	NAD(P)-binding domain superfamily