Gene

eomesa

ID

ZDB-GENE-001228-1

Name

eomesodermin homolog a

Symbol

eomesa Nomenclature History

Previous Names

eom-a (1)
eom (1)
eomes1 (1)
eomes
tbr2 (1)
tbr2a (1)

Type

protein_coding_gene

Location

Chr: 19 Mapping Details/Browsers

Description

Exhibits DNA binding activity and DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in several processes, including determination of dorsal identity; epiboly; and gastrulation. Localizes to cytoplasm and nucleus. Is expressed in several structures, including blastoderm; blastodisc; brain; eye; and immune system. Orthologous to human EOMES (eomesodermin).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

42 figures from 25 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu170 (12 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 7 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With eomesa Human Ortholog

No data available

Associated With eomesa Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018186	Transcription factor, T-box, conserved site
Domain	IPR032385	T-box transcription factor-associated
Domain	IPR046360	T-box transcription factor, DNA-binding domain
Family	IPR001699	T-box transcription factor
Homologous_superfamily	IPR008967	p53-like transcription factor, DNA-binding domain superfamily
Homologous_superfamily	IPR036960	T-box superfamily

Domain Details Per Protein

Protein	Length	p53-like transcription factor, DNA-binding domain superfamily	T-box superfamily	T-box transcription factor	T-box transcription factor-associated	T-box transcription factor, DNA-binding domain	Transcription factor, T-box, conserved site
UniProtKB:Q98TU2 InterPro	661

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	eomesa-201 (1) Ensembl	Ensembl	2,411 nt	Select Tool ZFIN BLAST
mRNA	eomesa-202 (1) Ensembl	Ensembl	2,507 nt	Select Tool ZFIN BLAST
mRNA	eomesa-203 (1) Ensembl	Ensembl	2,729 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-eomesa	polyclonal	eomesa		Rabbit	IHC WB		1

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations