Gene
kat6b
- ID
- ZDB-GENE-000607-52
- Name
- K(lysine) acetyltransferase 6B
- Symbol
- kat6b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable chromatin binding activity; histone H3 acetyltransferase activity; and transcription coregulator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within chromatin organization. Predicted to be part of MOZ/MORF histone acetyltransferase complex. Predicted to be active in chromatin and nucleus. Is expressed in forebrain. Human ortholog(s) of this gene implicated in Ohdo syndrome, SBBYS variant; bipolar disorder; breast cancer; and leiomyoma. Orthologous to human KAT6B (lysine acetyltransferase 6B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Kudoh et al., 2001
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Ohdo syndrome, SBBYS variant | Alliance | SBBYSS syndrome | 603736 |
| Genitopatellar syndrome | 606170 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001965 | Zinc finger, PHD-type |
| Domain | IPR002717 | Histone acetyltransferase domain, MYST-type |
| Domain | IPR005818 | Linker histone H1/H5, domain H15 |
| Domain | IPR019787 | Zinc finger, PHD-finger |
| Domain | IPR040706 | MYST, zinc finger domain |
| Domain | IPR048589 | SAM domain-containing protein 1-like, WH domain |
| Family | IPR050603 | MYST family histone acetyltransferases |
| Homologous_superfamily | IPR011011 | Zinc finger, FYVE/PHD-type |
| Homologous_superfamily | IPR013083 | Zinc finger, RING/FYVE/PHD-type |
| Homologous_superfamily | IPR016181 | Acyl-CoA N-acyltransferase |
| Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
| Homologous_superfamily | IPR036390 | Winged helix DNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Acyl-CoA N-acyltransferase | Histone acetyltransferase domain, MYST-type | Linker histone H1/H5, domain H15 | MYST family histone acetyltransferases | MYST, zinc finger domain | SAM domain-containing protein 1-like, WH domain | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily | Zinc finger, FYVE/PHD-type | Zinc finger, PHD-finger | Zinc finger, PHD-type | Zinc finger, RING/FYVE/PHD-type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3B851 | InterPro | 1856 | ||||||||||||
| UniProtKB:A0A8M3BER5 | InterPro | 2044 | ||||||||||||
| UniProtKB:A0A8M3B5C9 | InterPro | 1762 | ||||||||||||
| UniProtKB:A0A8M3AZ79 | InterPro | 2043 |
Interactions and Pathways
No data available
Plasmids
No data available