Gene
map3k4
- ID
- ZDB-GENE-990603-4
- Name
- mitogen-activated protein kinase kinase kinase 4
- Symbol
- map3k4 Nomenclature History
- Previous Names
-
- mekk4
- cb135 (1)
- fa02f11
- im:7137220
- si:ch211-67f13.5
- wu:fa02f11
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to have protein serine/threonine kinase activity. Predicted to be involved in several processes, including activation of protein kinase activity; signal transduction by protein phosphorylation; and stress-activated protein kinase signaling cascade. Predicted to localize to cytoplasm. Is expressed in several structures, including mesoderm; nervous system; neural plate; primordial germ cell; and tail bud. Orthologous to human MAP3K4 (mitogen-activated protein kinase kinase kinase 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb135 (25 images)
- IMAGE:7137220 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR045801 | Mitogen-activated protein kinase kinase kinase, N-terminal |
| Family | IPR050538 | Mitogen-activated protein kinase kinase kinase |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Mitogen-activated protein kinase kinase kinase | Mitogen-activated protein kinase kinase kinase, N-terminal | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A0R4IK63
|
1540 | ||||||
|
UniProtKB:A0A8M3B5F7
|
1539 | ||||||
|
UniProtKB:A0A8M9PYS2
|
1505 | ||||||
|
UniProtKB:A0A8M3AZE2
|
1506 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
map3k4-202
(1)
|
Ensembl | 5,567 nt | ||
| mRNA |
map3k4-203
(1)
|
Ensembl | 748 nt | ||
| ncRNA |
map3k4-002
(1)
|
Ensembl | 351 nt |
Interactions and Pathways
No data available
Plasmids
No data available