Gene

oxtrb

ID

ZDB-GENE-110805-1

Name

oxytocin receptor b

Symbol

oxtrb Nomenclature History

Previous Names

OTR(2) (1)
oxtlr1 (1)
oxtrl
itnpr-like 1 (1)

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Enables peptide hormone binding activity. Acts upstream of or within social behavior. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including eye; heart; integument; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in alcohol dependence; alcohol use disorder; personality disorder; and substance abuse. Orthologous to human OXTR (oxytocin receptor).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Chou et al., 2011

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Gemmer et al., 2022
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With oxtrb Human Ortholog

No data available

Associated With oxtrb Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR017452	GPCR, rhodopsin-like, 7TM
Family	IPR000276	G protein-coupled receptor, rhodopsin-like
Family	IPR001817	Vasopressin receptor
Family	IPR002062	Oxytocin receptor