Gene
comp
- ID
- ZDB-GENE-060606-1
- Name
- cartilage oligomeric matrix protein
- Symbol
- comp Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to have calcium ion binding activity. Predicted to be involved in cell adhesion. Predicted to localize to extracellular region. Human ortholog(s) of this gene implicated in multiple epiphyseal dysplasia 1; osteochondrodysplasia; and pseudoachondroplasia. Is expressed in several structures, including head mesenchyme; heart primordium; mesoderm; pectoral fin; and somite. Orthologous to human COMP (cartilage oligomeric matrix protein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7154332 (16 images)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Forte-Gomez et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| carpal tunnel syndrome 2 | Alliance | Carpal tunnel syndrome 2 | 619161 |
| multiple epiphyseal dysplasia 1 | Alliance | Epiphyseal dysplasia, multiple, 1 | 132400 |
| pseudoachondroplasia | Alliance | Pseudoachondroplasia | 177170 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018097 | EGF-like calcium-binding, conserved site |
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR001881 | EGF-like calcium-binding domain |
| Domain | IPR008859 | Thrombospondin, C-terminal |
| Domain | IPR024665 | Thrombospondin/cartilage oligomeric matrix protein, coiled-coil domain |
| Domain | IPR039081 | Thrombospondin-5, coiled coil domain |
| Domain | IPR049883 | NOTCH1 EGF-like calcium-binding domain |
| Homologous_superfamily | IPR013320 | Concanavalin A-like lectin/glucanase domain superfamily |
| Homologous_superfamily | IPR028974 | TSP type-3 repeat |
| Homologous_superfamily | IPR046970 | Thrombospondin/cartilage oligomeric matrix protein, coiled-coil domain superfamily |
| Repeat | IPR003367 | Thrombospondin, type 3-like repeat |
| Repeat | IPR017897 | Thrombospondin, type 3 repeat |
Domain Details Per Protein
| Protein | Length | Concanavalin A-like lectin/glucanase domain superfamily | EGF-like calcium-binding, conserved site | EGF-like calcium-binding domain | EGF-like domain | NOTCH1 EGF-like calcium-binding domain | Thrombospondin-5, coiled coil domain | Thrombospondin/cartilage oligomeric matrix protein, coiled-coil domain | Thrombospondin/cartilage oligomeric matrix protein, coiled-coil domain superfamily | Thrombospondin, C-terminal | Thrombospondin, type 3-like repeat | Thrombospondin, type 3 repeat | TSP type-3 repeat |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M6Z914
|
748 | ||||||||||||
|
UniProtKB:A0A0G2KDJ5
|
749 |
Interactions and Pathways
No data available
Plasmids
No data available