Gene

lars2

ID

ZDB-GENE-070928-3

Name

leucyl-tRNA synthetase 2, mitochondrial

Symbol

lars2 Nomenclature History

Previous Names

zgc:165522

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Description

Predicted to have leucine-tRNA ligase activity. Predicted to be involved in leucyl-tRNA aminoacylation and mitochondrial translation. Predicted to localize to mitochondrion. Human ortholog(s) of this gene implicated in Perrault syndrome. Orthologous to human LARS2 (leucyl-tRNA synthetase 2, mitochondrial).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Zhang et al., 2018

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With lars2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Perrault syndrome	Alliance	Perrault syndrome 4	615300
		Hydrops, lactic acidosis, and sideroblastic anemia	617021

Associated With lars2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR001412	Aminoacyl-tRNA synthetase, class I, conserved site
Domain	IPR002300	Aminoacyl-tRNA synthetase, class Ia
Domain	IPR013155	Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding
Domain	IPR025709	Leucyl-tRNA synthetase, editing domain
Family	IPR002302	Leucine-tRNA ligase
Homologous_superfamily	IPR009008	Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain
Homologous_superfamily	IPR009080	Aminoacyl-tRNA synthetase, class Ia, anticodon-binding
Homologous_superfamily	IPR014729	Rossmann-like alpha/beta/alpha sandwich fold