Gene
manf
- ID
- ZDB-GENE-060929-640
- Name
- mesencephalic astrocyte-derived neurotrophic factor
- Symbol
- manf Nomenclature History
- Previous Names
-
- im:6909481
- zgc:153327
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Involved in dopaminergic neuron differentiation. Predicted to localize to endoplasmic reticulum and extracellular space. Human ortholog(s) of this gene implicated in breast cancer; lung non-small cell carcinoma; pancreatic cancer; renal cell carcinoma; and squamous cell carcinoma. Is expressed in several structures, including axis; brain; hatching gland; pleuroperitoneal region; and sensory system. Orthologous to human MANF (mesencephalic astrocyte derived neurotrophic factor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6909481 (15 images)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Chen et al., 2012
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Diabetes, deafness, developmental delay, and short stature syndrome | 620651 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | ARMET, C-terminal | ARMET-like | ARMET, N-terminal | SAP domain superfamily |
|---|---|---|---|---|---|
|
UniProtKB:Q08CA7
|
180 |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-manf | polyclonal | IgG | Rabbit |
|
ProSci Incorporated
|
2 |
Plasmids
No data available