ZFIN ID: ZDB-GENE-060929-640
Gene Name: mesencephalic astrocyte-derived neurotrophic factor
Gene Symbol: manf
Sequence Ontology ID : SO:0000704

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Previous Names: im:6909481, zgc:153327

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(Including Attributions)
Location: Chr: 22 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Involved in dopaminergic neuron differentiation; predicted to localize to the endoplasmic reticulum and extracellular space; orthologous to human MANF (mesencephalic astrocyte derived neurotrophic  ...
GENE EXPRESSION
All Expression Data: 9 figures from 2 publications
Directly Submitted Expression Data: 6 figures (15 images) from Thisse et al., 2004 [IMAGE:6909481]
Wild-type Stages, Structures: Cleavage:64-cell (2.0h-2.25h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa37559 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Targeting reagents:
    PHENOTYPE
    Data: 3 figures from Chen et al., 2012
    Observed in:
    DISEASE ASSOCIATED WITH manf HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH manf VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process dopaminergic neuron differentiation (more)
    Cellular Component endoplasmic reticulum (more)
    Molecular Function molecular_function (more)
    GO Terms (all 5)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR019345 (1)
  • InterPro:IPR036361 (1)
  • Pfam:PF10208 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA manf-001 (1) 1637
    GENE PRODUCT DESCRIPTION No description available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM manf No data available
    MARKER RELATIONSHIPS
    manfContained in: [BAC] CH73-167F18 (1) (order this)
    manfEncodes: [EST] IMAGE:6909481 (1) (order this)
    [cDNA] MGC:153327 (1) (order this), MGC:192134 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001076629 (1) 1109bp
    Genomic GenBank:CU856621 (1) 95091bp
    Select Tool
    Polypeptide UniProtKB:A0A0B5JF91 (1) 180aa
    Sequence Clusters UniGene:14931 (1)
    Sequence Information (all 17)
    OTHER manf GENE PAGES
  • Alliance (1)
  • Gene:767691 (1)
  • VEGA:OTTDARG00000032918 (1)
  • ORTHOLOGY for manf (Chr: 22)
    CITATIONS (23)