Gene
nars2
- ID
- ZDB-GENE-060929-596
- Name
- asparaginyl-tRNA synthetase 2, mitochondrial
- Symbol
- nars2 Nomenclature History
- Previous Names
-
- zgc:153218
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to have ATP binding activity; asparagine-tRNA ligase activity; and nucleic acid binding activity. Predicted to be involved in asparaginyl-tRNA aminoacylation. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 94 and combined oxidative phosphorylation deficiency 24. Is expressed in female organism. Orthologous to human NARS2 (asparaginyl-tRNA synthetase 2, mitochondrial).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Newman et al., 2019
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive nonsyndromic deafness 94 | Alliance | ?Deafness, autosomal recessive 94 | 618434 |
| combined oxidative phosphorylation deficiency 24 | Alliance | Combined oxidative phosphorylation deficiency 24 | 616239 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR004364 | Aminoacyl-tRNA synthetase, class II (D/K/N) |
| Domain | IPR004365 | OB-fold nucleic acid binding domain, AA-tRNA synthetase-type |
| Domain | IPR006195 | Aminoacyl-tRNA synthetase, class II |
| Family | IPR002312 | Aspartyl/Asparaginyl-tRNA synthetase, class IIb |
| Family | IPR004522 | Asparagine-tRNA ligase |
| Homologous_superfamily | IPR012340 | Nucleic acid-binding, OB-fold |
| Homologous_superfamily | IPR045864 | Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL) |
Domain Details Per Protein
| Protein | Length | Aminoacyl-tRNA synthetase, class II | Aminoacyl-tRNA synthetase, class II (D/K/N) | Asparagine-tRNA ligase | Aspartyl/Asparaginyl-tRNA synthetase, class IIb | Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL) | Nucleic acid-binding, OB-fold | OB-fold nucleic acid binding domain, AA-tRNA synthetase-type |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q08CE2
|
485 | |||||||
|
UniProtKB:A0A8M9QLG1
|
505 |
Interactions and Pathways
No data available
Plasmids
No data available