Gene
slc30a8
- ID
- ZDB-GENE-060315-10
- Name
- solute carrier family 30 member 8
- Symbol
- slc30a8 Nomenclature History
- Previous Names
-
- wu:fe49g03
- ZnT8 (1)
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to have zinc ion transmembrane transporter activity. Involved in glucose homeostasis and type B pancreatic cell development. Predicted to localize to plasma membrane. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to several human genes including RPRD1A (regulation of nuclear pre-mRNA domain containing 1A).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 5 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from O'Hare et al., 2016
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
type 2 diabetes mellitus | Alliance | {Diabetes mellitus, noninsulin-dependent, susceptibility to} | 125853 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR006569 | CID domain |
Domain | IPR032337 | RPRD1A/B, C-terminal domain |
Domain | IPR047884 | RPRD1A, CID domain |
Family | IPR002524 | Cation efflux protein |
Homologous_superfamily | IPR008942 | ENTH/VHS |
Homologous_superfamily | IPR027469 | Cation efflux transmembrane domain superfamily |
Homologous_superfamily | IPR036837 | Cation efflux protein, cytoplasmic domain superfamily |
Domain Details Per Protein
Protein | Length | Cation efflux protein | Cation efflux protein, cytoplasmic domain superfamily | Cation efflux transmembrane domain superfamily | CID domain | ENTH/VHS | RPRD1A/B, C-terminal domain | RPRD1A, CID domain |
---|---|---|---|---|---|---|---|---|
UniProtKB:A0A8M9PGZ9
|
725 |
Type | Name | Annotation Method | Length (nt) | Analysis |
---|---|---|---|---|
mRNA |
slc30a8-201
(1)
|
Havana | 3839 nt |
Interactions and Pathways
No data available
Plasmids
No data available