ZFIN is now using GRCz12tu for Genomic Data
Gene
alox5b.3
- ID
- ZDB-GENE-050522-330
- Name
- arachidonate 5-lipoxygenase b, tandem duplicate 3
- Symbol
- alox5b.3 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable iron ion binding activity and oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen. Predicted to be involved in lipid oxidation. Predicted to be located in cytoplasm. Is expressed in EVL; head; and periderm. Human ortholog(s) of this gene implicated in artery disease (multiple); asthma (multiple); pancreatic cancer; and pulmonary tuberculosis. Orthologous to human ALOX5 (arachidonate 5-lipoxygenase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb171 (2 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR020833 | Lipoxygenase, iron binding site |
| Conserved_site | IPR020834 | Lipoxygenase, conserved site |
| Domain | IPR001024 | PLAT/LH2 domain |
| Domain | IPR013819 | Lipoxygenase, C-terminal |
| Family | IPR000907 | Lipoxygenase |
| Family | IPR001885 | Lipoxygenase, mammalian |
| Homologous_superfamily | IPR036226 | Lipoxigenase, C-terminal domain superfamily |
| Homologous_superfamily | IPR036392 | PLAT/LH2 domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Lipoxigenase, C-terminal domain superfamily | Lipoxygenase | Lipoxygenase, conserved site | Lipoxygenase, C-terminal | Lipoxygenase, iron binding site | Lipoxygenase, mammalian | PLAT/LH2 domain | PLAT/LH2 domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1R442 | InterPro | 676 | ||||||||
| UniProtKB:Q503R7 | InterPro | 676 | ||||||||
| UniProtKB:A0AC58HAY7 | InterPro | 676 | ||||||||
| UniProtKB:A0AC58HAZ4 | InterPro | 676 | ||||||||
| UniProtKB:A0AC58HB07 | InterPro | 676 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
alox5b.3-201
(1)
|
Ensembl | 2,576 nt | ||
| mRNA |
alox5b.3-204
(1)
|
Ensembl | 4,090 nt | ||
| ncRNA |
alox5b.3-002
(1)
|
Ensembl | 434 nt | ||
| ncRNA |
alox5b.3-003
(1)
|
Ensembl | 962 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers