Gene
kcnd2
- ID
- ZDB-GENE-041210-70
- Name
- potassium voltage-gated channel, Shal-related subfamily, member 2
- Symbol
- kcnd2 Nomenclature History
- Previous Names
-
- si:dkey-24j9.3
- si:dkeyp-97c5.3
- zShal2 (1)
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable A-type (transient outward) potassium channel activity. Predicted to be involved in action potential and potassium ion transmembrane transport. Predicted to act upstream of or within monoatomic ion transmembrane transport; potassium ion transport; and protein homooligomerization. Predicted to be located in several cellular components, including anchoring junction; perikaryon; and synapse. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in dendritic spine; neuronal cell body; and postsynaptic membrane. Orthologous to human KCND2 (potassium voltage-gated channel subfamily D member 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la024771Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa20218 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa20219 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-kcnd2 | LaCoursiere et al., 2024 | |
| CRISPR2-kcnd2 | LaCoursiere et al., 2024 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000210 | BTB/POZ domain |
| Domain | IPR003131 | Potassium channel tetramerisation-type BTB domain |
| Domain | IPR005821 | Ion transport domain |
| Domain | IPR021645 | Shal-type voltage-gated potassium channels, N-terminal |
| Domain | IPR024587 | Potassium channel, voltage dependent, Kv4, C-terminal |
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Domain Details Per Protein
| Protein | Length | BTB/POZ domain | Ion transport domain | Potassium channel tetramerisation-type BTB domain | Potassium channel, voltage dependent, Kv | Potassium channel, voltage dependent, Kv4 | Potassium channel, voltage dependent, Kv4.2 | Potassium channel, voltage dependent, Kv4, C-terminal | Shal-type voltage-gated potassium channels, N-terminal | SKP1/BTB/POZ domain superfamily | Voltage-dependent channel domain superfamily | Voltage-gated potassium channel |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M3B1N2
|
597 | |||||||||||
|
UniProtKB:Q5VSI1
|
630 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-24J9 | ZFIN Curated Data | |
| Contained in | BAC | DKEYP-97C5 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001082867 (1) | 1893 nt | ||
| Genomic | GenBank:AL929016 (1) | 200582 nt | ||
| Polypeptide | UniProtKB:Q5VSI1 (1) | 630 aa |
- LaCoursiere, C.M., Ullmann, J.F.P., Koh, H.Y., Turner, L., Baker, C.M., Robens, B., Shao, W., Rotenberg, A., McGraw, C.M., Poduri, A.H. (2024) Zebrafish models of candidate human epilepsy-associated genes provide evidence of hyperexcitability. iScience. 27:110172110172
- Tsata, V., Kroehne, V., Reinhardt, S., El-Armouche, A., Brand, M., Wagner, M., Reimer, M.M. (2019) Electrophysiological Properties of Adult Zebrafish Oligodendrocyte Progenitor Cells. Frontiers in Cellular Neuroscience. 13:102
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Wu, M., Wu, D., Wang, C., Guo, Z., Li, B., Zuo, Z. (2016) Hexabromocyclododecane exposure induces cardiac hypertrophy and arrhythmia by inhibiting miR-1 expression via up-regulation of the homeobox gene Nkx2.5. Journal of hazardous materials. 302:304-313
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Nakamura, T.Y., and Coetzee, W.A. (2008) Functional and pharmacological characterization of a Shal-related K+ channel subunit in Zebrafish. BMC Physiology. 8:2
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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