Gene

mep1a.2

ID

ZDB-GENE-041001-208

Name

meprin A, alpha (PABA peptide hydrolase), tandem duplicate 2

Symbol

mep1a.2 Nomenclature History

Previous Names

MEP1Ac (1)
si:dkey-30j22.6 (1)

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Description

Predicted to have metalloendopeptidase activity. Involved in positive regulation of angiogenesis. Predicted to localize to integral component of membrane. Is expressed in several structures, including epidermis; gill; heart; liver; and pleuroperitoneal region. Orthologous to human MEP1A (meprin A subunit alpha).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Schütte et al., 2010
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mep1a.2 Human Ortholog

No data available

Associated With mep1a.2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000742	EGF-like domain
Domain	IPR000998	MAM domain
Domain	IPR001506	Peptidase M12A
Domain	IPR002083	MATH/TRAF domain
Domain	IPR006026	Peptidase, metallopeptidase
Domain	IPR049342	TRAF1-6/MEP1A/B-like, MATH domain
Family	IPR008294	Meprin alpha/beta subunit
Homologous_superfamily	IPR008974	TRAF-like
Homologous_superfamily	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily
Homologous_superfamily	IPR024079	Metallopeptidase, catalytic domain superfamily

Domain Details Per Protein

Protein	Length	Concanavalin A-like lectin/glucanase domain superfamily	EGF-like domain	MAM domain	MATH/TRAF domain	Meprin alpha/beta subunit	Metallopeptidase, catalytic domain superfamily	Peptidase M12A	Peptidase, metallopeptidase	TRAF1-6/MEP1A/B-like, MATH domain	TRAF-like
UniProtKB:B3DKP9 InterPro	689

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	mep1a.2-202 (1) Ensembl	Havana	2694 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-mep1a.2	polyclonal	mep1a.2			IHC		1

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl
Note: This gene and mep1a.1 (ZDB-GENE-041001-209) are located next to each other in the genome and appear to be the result of a tandem duplication. The tandem duplicates appear to be the orthologs of human MEP1A and mouse Mep1a based on amino acid identity and conserved location.

Citations