ZFIN ID: ZDB-GENE-041001-208
Gene Name: meprin A, alpha (PABA peptide hydrolase), tandem duplicate 2
Gene Symbol: mep1a.2
Sequence Ontology ID : SO:0000704

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Previous Names: MEP1Ac (1), si:dkey-30j22.6 (1)

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(Including Attributions)
Location: Chr: 20 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have metalloendopeptidase activity; involved in positive regulation of angiogenesis; predicted to localize to the meprin A complex; orthologous to human MEP1A (meprin A subunit alpha).
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Wild-type Stages, Structures: Adult (90d-730d, breeding adult) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa11789 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa32309 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Targeting reagents:
    PHENOTYPE
    Data: 2 figures from Schütte et al., 2010
    Observed in:
    DISEASE ASSOCIATED WITH mep1a.2 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH mep1a.2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process positive regulation of angiogenesis (more)
    Cellular Component integral component of membrane (more)
    Molecular Function hydrolase activity (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000742 (1)
  • InterPro:IPR000998 (1)
  • InterPro:IPR001506 (1)
  • InterPro:IPR002083 (1)
  • InterPro:IPR006026 (1)
  • InterPro:IPR008294 (1)
  • InterPro:IPR008974 (1)
  • InterPro:IPR013320 (1)
  • InterPro:IPR024079 (1)
  • InterPro:IPR034301 (1)
  • PROSITE:PS00740 (1)
  • PROSITE:PS50026 (1)
  • PROSITE:PS50060 (1)
  • PROSITE:PS50144 (1)
  • Pfam:PF00008 (1)
  • Pfam:PF00629 (1)
  • Pfam:PF01400 (1)
  • EC:3.4.24.- (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA mep1a.2-001 (1) 2694
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM mep1a.2 No data available
    MARKER RELATIONSHIPS
    mep1a.2Contained in: [BAC] DKEY-30J22 (1) (order this)
    mep1a.2Encodes: [cDNA] MGC:195364 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001128727 (1) 2396bp
    Genomic GenBank:BX510920 (1) 220240bp Blast at MegaBLAST
    Polypeptide UniProtKB:B3DKP9 (1) 689aa
    Sequence Clusters UniGene:52671 (1)
    Sequence Information (all 12)
    OTHER mep1a.2 GENE PAGES
  • Alliance (1)
  • Gene:565535 (1)
  • VEGA:OTTDARG00000005938 (1)
  • Ensembl(GRCz11):ENSDARG00000008029 (2)
  • ORTHOLOGY for mep1a.2 (Chr: 20)
    CITATIONS (21)