ZFIN is now using GRCz12tu for Genomic Data
Gene
sars1
- ID
- ZDB-GENE-040831-1
- Name
- seryl-tRNA synthetase 1
- Symbol
- sars1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Enables serine-tRNA ligase activity. Involved in negative regulation of sprouting angiogenesis; negative regulation of vascular endothelial growth factor production; and seryl-tRNA aminoacylation. Acts upstream of or within branching involved in blood vessel morphogenesis; cerebellum vasculature development; and negative regulation of angiogenesis. Located in nucleus. Is expressed in several structures, including brain; digestive system; eye; immature eye; and musculature system. Used to study arteriovenous malformations of the brain. Human ortholog(s) of this gene implicated in intellectual disability and neurodevelopmental disorder with microcephaly, ataxia, and seizures. Orthologous to human SARS1 (seryl-tRNA synthetase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 14 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6908380 (8 images)
- IMAGE:7155143 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 21 figures from 10 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| neurodevelopmental disorder with microcephaly, ataxia, and seizures | Alliance | Neurodevelopmental disorder with microcephaly, ataxia, and seizures | 617709 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| arteriovenous malformations of the brain | pku6Tg + MO4-sars1 | standard conditions | Wang et al., 2018 |
| arteriovenous malformations of the brain | pku6Tg + MO1-sars1 | standard conditions | Wang et al., 2018 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR002314 | Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) |
| Domain | IPR006195 | Aminoacyl-tRNA synthetase, class II |
| Domain | IPR015866 | Serine-tRNA synthetase, type1, N-terminal |
| Domain | IPR033729 | Serine-tRNA ligase catalytic core domain |
| Family | IPR002317 | Serine-tRNA ligase, type1 |
| Homologous_superfamily | IPR010978 | Class I and II aminoacyl-tRNA synthetase, tRNA-binding arm |
| Homologous_superfamily | IPR042103 | Serine-tRNA synthetase, type1, N-terminal domain superfamily |
| Homologous_superfamily | IPR045864 | Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL) |
Domain Details Per Protein
| Protein | Additional Resources | Length | Aminoacyl-tRNA synthetase, class II | Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) | Class I and II aminoacyl-tRNA synthetase, tRNA-binding arm | Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL) | Serine-tRNA ligase catalytic core domain | Serine-tRNA ligase, type1 | Serine-tRNA synthetase, type1, N-terminal | Serine-tRNA synthetase, type1, N-terminal domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6DRC0 | InterPro | 515 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers