Gene

sars1

ID
ZDB-GENE-040831-1
Name
seryl-tRNA synthetase 1
Symbol
sars1 Nomenclature History
Previous Names
  • adr (1)
  • sars (1)
  • adrasteia (1)
  • unm s277 (1)
  • unm_s277 (1)
  • wu:fk51f08 (1)
  • zgc:92152 (1)
Type
protein_coding_gene
Location
Chr: 23 Mapping Details/Browsers
Description
Exhibits serine-tRNA ligase activity. Involved in several processes, including negative regulation of vascular endothelial growth factor production; seryl-tRNA aminoacylation; and vasculature development. Localizes to nucleus. Used to study arteriovenous malformations of the brain. Is expressed in several structures, including alar plate midbrain region; immature eye; liver; midbrain; and musculature system. Orthologous to human SARS1 (seryl-tRNA synthetase 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
10 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
19 figures from 9 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With sars1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
?Neurodevelopmental disorder with microcephaly, ataxia, and seizures 617709
Associated With sars1 Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR002314 Aminoacyl-tRNA synthetase, class II (G/ P/ S/T)
Domain IPR006195 Aminoacyl-tRNA synthetase, class II
Domain IPR015866 Serine-tRNA synthetase, type1, N-terminal
Domain IPR033729 Serine-tRNA ligase catalytic core domain
Family IPR002317 Serine-tRNA ligase, type1
Homologous_superfamily IPR010978 Class I and II aminoacyl-tRNA synthetase, tRNA-binding arm
Homologous_superfamily IPR042103 Serine-tRNA synthetase, type1, N-terminal domain superfamily
Domain Details Per Protein
Protein Length Aminoacyl-tRNA synthetase, class II Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) Class I and II aminoacyl-tRNA synthetase, tRNA-binding arm Serine-tRNA ligase catalytic core domain Serine-tRNA ligase, type1 Serine-tRNA synthetase, type1, N-terminal Serine-tRNA synthetase, type1, N-terminal domain superfamily
UniProtKB:Q6DRC0 515
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-sars monoclonal IgG2a , k Mouse
  • WB
Abnova
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations