ZFIN ID: ZDB-GENE-040831-1
Gene Name: seryl-tRNA synthetase 1
Gene Symbol: sars1    Nomenclature History

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Previous Names: adr (1), sars, adrasteia (1), unm s277 (1), unm_s277 (1), wu:fk51f08 (1), zgc:92152 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 23 Mapping Details/Browsers
Description: Exhibits serine-tRNA ligase activity. Involved in several processes, including negative regulation of vascular endothelial growth factor production; seryl-tRNA aminoacylation; and vasculature development. Localizes to nucleus. Is expressed in several structures, including alar plate midbrain region; immature eye; liver; midbrain; and musculature system. Used to study arteriovenous malformations of the brain. Orthologous to human SARS1 (seryl-tRNA synthetase 1).
Genome Resources: Alliance (1),  Gene:445405 (1),  Ensembl(GRCz11):ENSDARG00000008237 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hi3817Tg Transgenic Insertion Intron 1 Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • ko095 Point Mutation Unknown Unknown ENU
    la022685Tg Transgenic Insertion Unknown Unknown DNA
    s228 Point Mutation Unknown Premature Stop ENU
    s277 Point Mutation Unknown Missense ENU
    sa382 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa3234 Point Mutation Unknown Splice Site ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-sars1 N/A 4
    MO2-sars1 N/A 1
    MO3-sars1 N/A 1
    MO4-sars1 N/A 1
    DISEASE ASSOCIATED WITH sars1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    ?Neurodevelopmental disorder with microcephaly, ataxia, and seizures 617709
    DISEASE ASSOCIATED WITH sars1 VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    arteriovenous malformations of the brain pku6Tg + MO1-sars standard conditions Wang et al., 2018
    pku6Tg + MO4-sars standard conditions Wang et al., 2018
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process negative regulation of vascular endothelial growth factor production (more)
    Cellular Component nucleus (more)
    Molecular Function serine-tRNA ligase activity (more)
    GO Terms (all 23)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA sars-201 (1)    Ensembl 2286
    ncRNA sars-002 (1)    Ensembl 981
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-sars monoclonal IgG2a , k Mouse WB Abnova
    2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM sars1 No data available
    MARKER RELATIONSHIPS
    sars1 Contained in: [BAC] CH211-207E14 (1)
    sars1 Encodes: [EST] fk51f08 (1), IMAGE:6908380 (1), IMAGE:7155143 (1)
    [cDNA] MGC:92152
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001003882 (1) 2286 nt
    Genomic GenBank:AL954678 (1) 219500 nt Blast at MegaBLAST
    Polypeptide UniProtKB:Q6DRC0 (1) 515 aa
    Sequence Information (all 17)
    ORTHOLOGY for sars1 ( Chr: 23 )
    CITATIONS (46)