ZFIN ID: ZDB-GENE-040831-1
Gene Name: seryl-tRNA synthetase
Gene Symbol: sars
Sequence Ontology ID : SO:0000704

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Previous Names: adr (1), adrasteia (1), unm s277 (1), unm_s277 (1), wu:fk51f08 (1), zgc:92152 (1)

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(Including Attributions)
Location: Chr: 23 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Exhibits serine-tRNA ligase activity; involved in several processes, including branching involved in blood vessel morphogenesis, negative regulation of sprouting angiogenesis, and negative regulation  ...
GENE EXPRESSION
All Expression Data: 10 figures from 3 publications
Directly Submitted Expression Data: 6 figures (8 images) from Thisse et al., 2004 [IMAGE:6908380]
  1 figure (1 image) from Thisse et al., 2004 [IMAGE:7155143]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hi3817Tg Transgenic Insertion Intron 1 Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • ko095 Point Mutation Unknown Unknown ENU
    la022685Tg Transgenic Insertion Unknown Unknown DNA
    s228 Point Mutation Unknown Premature Stop ENU
    s277 Point Mutation Unknown Missense ENU
    sa382 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa3234 Point Mutation Unknown Splice Site ENU
    Targeting reagents:
    PHENOTYPE
    Data: 19 figures from 9 publications
    Observed in:
    DISEASE ASSOCIATED WITH sars HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    ?Neurodevelopmental disorder with microcephaly, ataxia, and seizures 617709
    DISEASE ASSOCIATED WITH sars VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    arteriovenous malformations of the brain pku6Tg + MO1-sars standard conditions Wang et al., 2018
    pku6Tg + MO4-sars standard conditions Wang et al., 2018
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process negative regulation of vascular endothelial growth factor production (more)
    Cellular Component nucleus (more)
    Molecular Function serine-tRNA ligase activity (more)
    GO Terms (all 21)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR002314 (1)
  • InterPro:IPR002317 (1)
  • InterPro:IPR006195 (1)
  • InterPro:IPR010978 (1)
  • InterPro:IPR015866 (1)
  • InterPro:IPR033729 (1)
  • PROSITE:PS50862 (1)
  • Pfam:PF00587 (1)
  • Pfam:PF02403 (1)
  • EC:6.1.1.11 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    ncRNA sars-002 (1) 981
    mRNA sars-201 (1) 2286
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM sars No data available
    MARKER RELATIONSHIPS
    sarsContained in: [BAC] CH211-207E14 (1) (order this)
    sarsEncodes: [EST] fk51f08 (1), IMAGE:6908380 (1) (order this), IMAGE:7155143 (1) (order this)
    [cDNA] MGC:92152 (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001003882 (1) 2286bp
    Genomic GenBank:AL954678 (1) 219500bp Blast at MegaBLAST
    Polypeptide UniProtKB:Q6DRC0 (1) 515aa
    Sequence Clusters UniGene:32657 (1)
    Sequence Information (all 18)
    OTHER sars GENE PAGES
  • Alliance (1)
  • Gene:445405 (1)
  • VEGA:OTTDARG00000021275 (1)
  • Ensembl(GRCz11):ENSDARG00000008237 (2)
  • ORTHOLOGY for sars (Chr: 23)
    CITATIONS (43)