Gene

tpm2

ID

ZDB-GENE-040625-114

Name

tropomyosin 2 (beta)

Symbol

tpm2 Nomenclature History

Previous Names

cb836 (1)
fj63f03
tpm4l (1)
wu:fj63f03
zgc:86810 (1)

Type

protein_coding_gene

Location

Chr: 10 Mapping Details/Browsers

Description

Predicted to have actin filament binding activity. Predicted to be involved in actin filament organization and muscle contraction. Localizes to striated muscle thin filament. Human ortholog(s) of this gene implicated in distal arthrogryposis type 1A and nemaline myopathy 4. Is expressed in adaxial cell; cardiovascular system; epiphysis; musculature system; and somite. Orthologous to human TPM2 (tropomyosin 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

13 figures from 4 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

cb836 (16 images)
IMAGE:6892450 (10 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tpm2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
distal arthrogryposis type 1A	Alliance	Arthrogryposis, distal, type 1A	108120
distal arthrogryposis type 1A	Alliance	Arthrogryposis, distal, type 2B4	108120
nemaline myopathy 4	Alliance	Congenital myopathy 23	609285

Associated With tpm2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR000533	Tropomyosin
Homologous_superfamily	IPR014751	DNA repair protein XRCC4-like, C-terminal

Domain Details Per Protein

Protein	Length	DNA repair protein XRCC4-like, C-terminal	Tropomyosin
UniProtKB:A0A8M2B1Q6 InterPro	284
UniProtKB:A0A8M2B1K3 InterPro	284
UniProtKB:A0A8M2B255 InterPro	248
UniProtKB:A0A8M2B1Q8 InterPro	248
UniProtKB:A0A8M2B2D1 InterPro	248
UniProtKB:Q6IQD7 InterPro	284
UniProtKB:A0A0R4IAL5 InterPro	248
UniProtKB:A0A0R4IM99 InterPro	284

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	tpm2-203 (1) Ensembl	Havana	863 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	tpm2-204 (1) Ensembl	Havana	3616 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	tpm2-205 (1) Ensembl	Havana	691 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	tpm2-206 (1) Ensembl	Havana	1305 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	tpm2-004 (1) Ensembl	Havana	805 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations