Gene
ctcf
- ID
- ZDB-GENE-040624-5
- Name
- CCCTC-binding factor (zinc finger protein)
- Symbol
- ctcf Nomenclature History
- Previous Names
-
- im:7152666
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Enables chromatin binding activity. Acts upstream of or within regulation of transcription by RNA polymerase II and skeletal muscle tissue development. Predicted to be located in nucleus. Is expressed in brain; digestive system; immature eye; notochord; and somite. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 21; basal cell carcinoma; female breast cancer; skin melanoma; and skin squamous cell carcinoma. Orthologous to human CTCF (CCCTC-binding factor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7152666 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 15 figures from 7 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant intellectual developmental disorder 21 | Alliance | Intellectual developmental disorder, autosomal dominant 21 | 615502 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | CTCF-like, C2H2 zinc finger | Zinc finger C2H2 superfamily | Zinc finger C2H2-type |
|---|---|---|---|---|---|
| UniProtKB:Q6JAA4 | InterPro | 798 | |||
| UniProtKB:A0AB32T4N5 | InterPro | 809 |
Interactions and Pathways
No data available
Plasmids
No data available