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ZIRC
ZFIN ID: ZDB-GENE-040624-5
Gene Name: CCCTC-binding factor (zinc finger protein)
Gene Symbol: ctcf    Nomenclature History

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Previous Name: im:7152666

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 18 Mapping Details/Browsers
Description: Exhibits chromatin binding activity. Involved in regulation of transcription by RNA polymerase II. Predicted to localize to the nucleus. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability 21. Is expressed in brain; digestive system; immature eye; notochord; and somite. Orthologous to human CTCF (CCCTC-binding factor).
Genome Resources: Alliance (1),  Gene:415104 (1),  Ensembl(GRCz11):ENSDARG00000056621 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hi870Tg Transgenic Insertion Intron 1 Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa14093 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa45637 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-ctcf
    1
    MO1-ctcf N/A 3
    MO2-ctcf N/A 3
    MO3-ctcf N/A 3
    MO4-ctcf N/A 2
    MO5-ctcf N/A 1
    MO6-ctcf N/A 1
    DISEASE ASSOCIATED WITH ctcf HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    autosomal dominant non-syndromic intellectual disability 21 Alliance Mental retardation, autosomal dominant 21 615502
    DISEASE ASSOCIATED WITH ctcf VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of gene expression (more)
    Cellular Component nucleus (more)
    Molecular Function chromatin binding (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR013087 (1)
  • InterPro:IPR036236 (1)
  • PROSITE:PS00028 (1)
  • PROSITE:PS50157 (1)
  • Pfam:PF00096 (1)
  • TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ctcf-201 (1)    Ensembl 4265
    ctcf-202 (1)    Ensembl 253
    ctcf-203 (1)    Ensembl 572
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-ctcf polyclonal Rabbit IHC, WB 1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ctcf No data available
    MARKER RELATIONSHIPS
    ctcf Contained in: [BAC] DKEY-6E12 (1) (order this)
    ctcf Encodes: [EST] IMAGE:7152666 (1) (order this)
    [cDNA] MGC:195365 (1) (order this), MGC:195371 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001001844 (1) 4244 bp
    Genomic GenBank:BX088593 (1) 251217 bp Blast at MegaBLAST
    Polypeptide UniProtKB:A0A2R8QUZ1 (1) 809 aa
    Sequence Clusters UniGene:53867 (1)
    Sequence Information (all 35)
    ORTHOLOGY for ctcf ( Chr: 18 )
    CITATIONS (37)