Gene
gdf11
- ID
- ZDB-GENE-040427-2
- Name
- growth differentiation factor 11
- Symbol
- gdf11 Nomenclature History
- Previous Names
-
- bmp11 (1)
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to have cytokine activity. Involved in anterior/posterior pattern specification. Predicted to localize to extracellular space. Is expressed in several structures, including brain; gonad; head; intermediate cell mass of mesoderm; and tail bud. Orthologous to human GDF11 (growth differentiation factor 11).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| vertebral hypersegmentation and orofacial anomalies | Alliance | ?Vertebral hypersegmentation and orofacial anomalies | 619122 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017948 | Transforming growth factor beta, conserved site |
| Domain | IPR001111 | TGF-beta, propeptide |
| Domain | IPR001839 | Transforming growth factor-beta, C-terminal |
| Family | IPR015615 | Transforming growth factor-beta-related |
| Homologous_superfamily | IPR029034 | Cystine-knot cytokine |
Domain Details Per Protein
| Protein | Length | Cystine-knot cytokine | TGF-beta, propeptide | Transforming growth factor beta, conserved site | Transforming growth factor-beta, C-terminal | Transforming growth factor-beta-related |
|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2B1U5
|
389 | |||||
|
UniProtKB:Q8JFP9
|
390 | |||||
|
UniProtKB:A0A8M6Z378
|
229 |
Interactions and Pathways
No data available
Plasmids
No data available